Constipation – Pipeline Review, 2019

Constipation is defined as the condition of the digestive system in which the individual experience bowel movements less than three times in a week and has hard stool making it difficult to expel. Causes for constipation include fewer bowel movements, depression, dehydration, colon cancer, pelvic floor disorders, irritable bowel syndrome, and others. Constipation can also result from the excessive intake of opioids, which is called as opioid-induced constipation.

Current treatment for constipation includes the use of drugs and lifestyle changes. Over-the-counter laxatives such as fiber supplements, saline laxatives, stimulants, lubricants, stool softeners, chloride channel activators, 5- Hydroxytryptamine -4 agonists are often used for the treatment of constipation. Lifestyle changes for the management of constipation include regular exercise, intake of fiber-rich food, intake of plenty of water, and others.

The risk of complications associated with chronic constipation such as rectal bleeding, anal fissure, inflamed blood vessels of veins, etc. are the major factors that focus on the need for the development of new and effective drugs. Thus, various pharmaceutical companies and research institutes are focusing on developing new treatment options for constipation. For instance; TD-1211, which is being studied by Theravance Biopharma, is currently in phase 2 clinical trials for the treatment of patients with opioid-induced constipation.

At present, around 33% of the pipeline candidates for constipation are in phase 2 clinical stage. Majority of the studies are sponsored by pharmaceutical industries.

Report Description

The report on ‘Constipation – Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for Constipation. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for Constipation.

The report on ‘Constipation – Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.

Report Scope

• A thorough assessment of the pipeline products by areas such as development stage; route of administration; drug class; indication; sponsor; molecule type and drug target
• Comprehensive profiles of the pipeline products with details such as company overview; product description; R&D status; development activities; mechanism of action; molecule type; development stage; indications; funding and route of administration
• Overview of dormant and discontinued pipeline products
• Key insights in relation to the epidemiology of conditions being treated by the pipeline products and overview of the addressable or current market for the pipeline products
• Overview of the latest developments; news articles, press releases, and relevant conferences

Report Methodology

• All pipeline reports are built through the analysis of data primarily collected through credible desk research sources. Secondary research is supplemented by interviews conducted with key opinion leaders.
• Desk research sources include global and regional clinical trials databases; annual reports, websites, press releases & investor presentations of companies; white papers; news articles; reports published by industry associations; articles/reports published on databases such as NCBI, ResearchGate; internal databases

Reasons to Buy this Report

• Develop effective growth strategies based on a comprehensive overview of the R&D activity and pipeline products for Constipation
• Identify emerging players or competition in the market based on pipeline products and develop strategies to counter the emergence of these players
• Identify the focus of leading players in relation to R&D for Constipation
• Identify potential companies from a partnership or acquisition point of view based on current synergy in R&D activities or strategies to diversify R&D focus to drive growth in business
• Analyze the reasons behind dormant and discontinued products to make changes in the R&D focus if necessary