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Constipation is defined as the condition of the digestive system in which the individual experience bowel movements less than three times in a week and has hard stool making it difficult to expel. Causes for constipation include fewer bowel movements, depression, dehydration, colon cancer, pelvic floor disorders, irritable bowel syndrome, and others. Constipation can also result from the excessive intake of opioids, which is called as opioid-induced constipation.
Current treatment for constipation includes the use of drugs and lifestyle changes. Over-the-counter laxatives such as fiber supplements, saline laxatives, stimulants, lubricants, stool softeners, chloride channel activators, 5- Hydroxytryptamine -4 agonists are often used for the treatment of constipation. Lifestyle changes for the management of constipation include regular exercise, intake of fiber-rich food, intake of plenty of water, and others.
The risk of complications associated with chronic constipation such as rectal bleeding, anal fissure, inflamed blood vessels of veins, etc. are the major factors that focus on the need for the development of new and effective drugs. Thus, various pharmaceutical companies and research institutes are focusing on developing new treatment options for constipation. For instance; TD-1211, which is being studied by Theravance Biopharma, is currently in phase 2 clinical trials for the treatment of patients with opioid-induced constipation.
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At present, around 33% of the pipeline candidates for constipation are in phase 2 clinical stage. Majority of the studies are sponsored by pharmaceutical industries.
The report on ‘Constipation – Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for Constipation. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for Constipation.
The report on ‘Constipation – Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.