Hydroxyproline Market Size, Share, and Industry Analysis, By Grade (Pharmaceutical Grade and Industrial Grade), By End User (Pharmaceutical & Biotechnological Companies, Cosmeceutical Companies, Nutraceutical Companies, and Others), and Regional Forecast, 2025-2032

The global hydroxyproline market is witnessing significant growth owing to the soaring awareness about health and wellness among the general population, resulting in the rising demand for nutritional supplements, collagen-based products, among others. Hydroxyproline is an amino acid mainly used for the production of collagen. The growing demand for collagen based products is likely to augment the product demand.

• According to a 2024 study published by Beauty Matter, it was reported that approximately 82% of consumers consider wellness an important priority in the U.S.

The growing demand for health and wellness products is likely to support the focus of key players to develop and introduce novel collagen-based products in the market. 

Hydroxyproline Market Driver

Increasing Demand for Collagen-Based Products to Drive the Market Growth

There is an increasing prevalence of orthopedic disorders, and acute and chronic wounds, among others, resulting in the rising demand for collagen-based products such as skin care products, nutraceutical products, among others. This growing demand is resulting in the rising number of R&D activities among key players to launch novel products, boosting the product demand.

• In February 2024, BrainMD launched the Smart Collagen supplement for optimal brain, joint and skin health with an aim to strengthen its product portfolio. The company also mentioned that its product is different from other conventional products owing to the 30 times higher concentration of proline-hydroxyproline (PO) and hydroxyproline-glycine (OG).

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According to the Centers for Disease Control and Prevention (CDC), it was reported that the prevalence of osteoarthritis is 32.5 million in the U.S., 10.0 million in the U.K., 11.2 million in Germany, 8.7 million in France, and 8.8 million in Italy in 2023.

Hydroxyproline Market Restraint

Side Effects Associated with Collagen Supplements May Hamper Market Growth

There is a growing adoption of hydroxyproline for the production of collagen based products such as supplements, among others, in the market. However, side effects associated with these products are likely to hamper the adoption rate of hydroxyproline.

• According to 2024 statistics published in Advanced of Urology, it was reported that the excessive intake of certain types of collagen, specifically derived from animal sources, may increase the risk of developing kidney stones.

Hydroxyproline Market Opportunity

Rising Research and Development Activities to Promote Product Adoption

There are ongoing research and development activities focusing on widening the application range for hydroxyproline. The expansion of the application range is likely to support the growing demand for this product, resulting in the rising focus of key players on manufacturing activities.

• According to 2024 data published by the National Center for Biotechnology Information (NCBI), it was reported that hydroxyproline is being studied as an experimental medicine for therapeutic purposes.

Segmentation

Key Insights

The report covers the following key insights:

• Prevalence of Key Diseases, By Key Countries, 2023
• Overview: Applications of Hydroxyproline
• Key Industry Developments (Mergers, Acquisitions, and Partnerships)
• Impact of COVID-19 on the Market 

Analysis by Grade

By grade, the market is segmented into pharmaceutical grade and industrial grade.

The industrial grade segment held the prominent market share in 2023. The growing demand for collagen based products such as skin care products, dietary supplements, among others, is resulting in the rising focus of key players toward the development of these products, supporting the segmental growth in the market.

• In June 2023, Revive Collagen launched its collagen supplement brand Revive Collagen with an aim to strengthen its presence in Europe. Thus, a growing number of product launches for dietary supplements, among others, is likely to augment the demand for hydroxyproline.

Analysis by End User

By end user, the market is segmented into pharmaceutical & biotechnological companies, cosmeceutical companies, nutraceutical companies, and others.

The cosmeceutical companies segment accounted for a substantial market share in 2023. The growth of the segment is due to various research and development activities to launch collagen-based skin care products in the market. This, along with growing inorganic growth strategies such as acquisitions and mergers among key players to strengthen their presence, is likely to support the segment growth.

• In August 2024, Kenvue launched Neutrogena Collagen Bank, featuring Kenvue’s patented micro-peptide technology. This launch enabled the company to move into the pre-aging category to meet the demand for skin aging among the population.

Regional Analysis

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By region, the market has been studied across North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

North America accounted for the largest share of the global hydroxyproline market in 2023. The regional growth is owing to several factors, including the rising prevalence of skin disorders, joint and pain conditions, and others, and growing healthcare expenditure.

• According to 2023 statistics published by the Yale School of Medicine, it was reported that about one in four people are affected by skin health in the U.S. Thus, the growing prevalence of skin disorders is supporting the rising demand for collagen based products, driving the regional market growth.

Europe is the second-largest market based on the demand for hydroxyproline. The rising awareness about health and wellness products among the general population is resulting in the growing demand for these products in the market. The increasing demand for these products is further driving the focus of key players toward acquisitions and mergers to strengthen their presence in the market.

The Asia Pacific market is expected to grow at a considerable CAGR during the forecast period. The growth is due to the rising number of clinical studies among key players studying the application of hydroxyproline in therapeutic medicine, which increases the product demand.

• For instance, according to a 2023 study published by the Japan Society for the Promotion of Science, hydroxyproline is an effective therapeutic agent for muscular atrophy among the patient population. Thus, the growing number of clinical studies, among other factors, is likely to support the regional market growth.

Key Players Covered

The competitive landscape of the global hydroxyproline market is semi-consolidated, with few players accounting for a prominent share of the global market. The market also depicts a growing number of acquisitions and mergers among major players to strengthen its presence in the collagen sector.  

The report includes the profiles of the following key players:

• Quickzyme Biosciences (The Netherlands)
• HQ Biosciences (U.S.)
• Human Biosciences (U.S.)
• KYOWA HAKKO BIO CO.,LTD. (Japan)
• AECOCHEM (U.S.)
• Fengchen Group Co.,Ltd. (China)
• Merck KGaA (Germany)
• Ningbo Create-Bio Engineering Co.,Ltd. (China)

Key Industry Developments

• In May 2024, Adroit Biomed Ltd., launched their technologically advanced high-performance, collagen product of “Fortisil C” with an aim to strengthen its product portfolio.
• In April 2023, Darling Ingredients acquired Gelnex, a Brazillian gelatin and collagen manufacturer, with an aim to increase its brand presence.