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Anaplastic astrocytoma is a rare malignant brain tumor. Astrocytomas develop from star-shaped brain cells called astrocytes. Astrocytomas are classified on the basis of the grading system provided by World Health Organization (WHO). The grading system is designed on the basis of the size of the tumor. Anaplastic astrocytomas are grade III astrocytomas. Symptoms observed in the patients suffering from anaplastic astrocytomas include headaches, lethargy, vomiting, and changes mental status or personality. In rare cases, seizures, vision problems, weakness in the arms and legs resulting in coordination difficulties are also observed.
Current treatment for anaplastic astrocytoma includes radiation, surgery, and chemotherapy. Food and Drug Administration (FDA) has approved temozolomide (Temodar) for the treatment of adults with anaplastic astrocytoma.
Research Institutes and pharmaceutical companies have focussed on studying and developing new methods for the treatment of anaplastic astrocytoma. For instance; ADV/HSV-tk (gene therapy), which is being studied by the Methodist Hospital System, is currently in phase-2 clinical trials for the study of the safety and efficacy of HSV-tk (gene therapy), valacyclovir, radiotherapy and chemotherapy in newly diagnosed glioblastoma multiforme (GBM) or anaplastic astrocytoma (AA).
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Currently, more than 60% of the pipeline candidates for anaplastic astrocytoma are in the phase 1 clinical stage. Majority of the studies have been sponsored by research institutes and hospitals.
The report on ‘Anaplastic Astrocytoma – Pipeline Review, 2020’ provides a comprehensive overview of the drugs that are in the R&D pipeline for anaplastic astrocytoma. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, and details such as sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for anaplastic astrocytoma.
The report on ‘Anaplastic Astrocytoma – Pipeline Review, 2020’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.
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