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The global anaplastic astrocytoma pipeline has expanded and developed with ongoing research for investigating the exact cause of the disease, which is still unknown. Anaplastic astrocytoma is an uncommon malignant brain tumor that is developed from certain star-shaped brain cells called astrocytes. The tumor arises from glial tissue which is collectively called as gliomas. This disease develops slowly over time; however, it may also develop rapidly.
The symptoms of this disorder differ, depending on location and sizes of the tumor are pushing for development of anaplastic astrocytoma therapeutics. According to researchers, the disease occurs due to rising genetic and immunological abnormalities and various environmental factors. Some other factors include diet and stress which causes specific types of cancer. Hence, investigators are actively working toward learning more about factors of cancer among the population. Rise in awareness of the disease and increased healthcare infrastructure boost market expansion in coming years.
Covering 15+ companies and 15+ pipeline drugs, Fortune Business Insights has released its report “Anaplastic Astrocytoma Pipeline Insights 2025”. It provides a complete pipeline insight regarding clinical research and non-clinical research of drug manufacturing and develops novel treatment of anaplastic astrocytoma based on commercial assessment and clinical assessment, and mechanism of action of the drugs. This report also provides pipeline review, including phase 1, phase 2, and phase 3 trials of drug development and treatments. The report covers regions such as North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
The growing requirement for effective therapeutic solutions for tumor treatment is fostering the demand for the drugs that are impelling R&D activities. There are numerous healthcare institutes, players associated with the medical sectors, and various research organizations are conducting clinical trials for developing new drugs for treatment of astrocytoma disorder. Government bodies have heightened the emphasis on enhancing infrastructure for healthcare contributing to the worldwide clinical trials scenario in the field of anaplastic astrocytoma treatment. Research is also happening to undertake the challenges related with the therapy.
Mounting awareness activities and supportive government policies have encouraged development initiatives for products. Various new drug candidates are in their preclinical and discovery stages and are in their Phase 1, Phase 2, and Phase 3 trials. There are other developments in the market including mergers, collaborations, and licensing as well as thorough therapeutic assessment for emerging drugs. To bring candidates to the market, major healthcare companies are keen to seek drug approvals from regulatory bodies.
Here’s a brief insight into some of the upcoming drugs in pipeline:
Eflornithine is also known as α-diflurormethylornithine (DFMO). It selectively targets and irreversibly obstructs ornithine decarboxylase (ODC). The ODC enzyme is essential for polyamine synthesis and RNA and DNA function. Its administration is seen to be potentiating the anti-tumor activity of other chemotherapy agents. In controlled and single-arm, randomized clinical trials, eflornithine oral solution increased survival in patients with both newly diagnosed and recurrent anaplastic glioma. The main and reversible side effects of eflornithine are hearing impairment and diarrhea.
Zotiracicilib is a powerful oral spectrum selective kinase inhibitor for the treatment of cancer. It is discovered by Singapose by S*BIO Pte Ltd and comes under the category of small molecule macrocycles. It passes the blood brain barriers and performs by depleting Myc through the inhibition of cyclin-dependent kinase 9. In October 2021, Cothera Bioscience Inc. and Adastra Pharmaceuticals Inc. unveiled a definitive agreement involving the acquisition of zotiraciclib (ZTR) by Cothera.
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