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Cachexia is the loss of fat and muscle due to a chronic disease, such as cancer, chronic renal failure, HIV and others. Cachexia causes loss of appetite, weight loss, fatigue and weakness. Cancer cachexia or cancer-induced cachexia is associated with presence of tumors. It affects an estimated 60% of the 1.6 million cancer patients in the U.S., alone. The prevalence of cachexia in cancer patients is an estimated 80% among late-stage cancer patients, and cancer-induced cachexia is responsible for around 20% deaths among cancer patients globally. The prevalence of cancer-induced cachexia differs depending upon the location of the cancer, ranging from 60% in lung cancer patients, to more than 80% among pancreatic and colorectal cancer patients.
There is no adequate treatment to treat cancer cachexia. Some of the commonly referred treatments are adequate diet, intake of nutrition supplement, exercise, medications. The medications include, Megace (megestrol), Thalidomide, Zyloprim (allopurinol), Celebrex (celecoxib), L-Carnitine and many others.
Pharmaceutical companies and research institutes have focussed on studying and developing new methods for the treatment of cancer cachexia. For instance; OHR/AVR118, which is being studied by Ohr Pharmaceutical Inc., is currently in phase-2 clinical trials for open label study with OHR/AVR118 in advanced cancer patients with Anorexia-Cachexia.
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At present more than 60% of the pipeline candidates for cancer cachexia are in phase 2 and phase 3 stages combined. Majority of the studies have been sponsored by pharmaceutical companies.
The report on ‘Cancer cachexia– Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for allergic conjunctivitis. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for cancer cachexia.
The report on ‘Cancer cachexia– Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.
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