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Diarrhea is characterized by loose, abnormal, and frequent bowel movement and is one of the most common health problems. According to the World Gastroenterology Organization, an estimated 2 billion cases of diarrhea are recorded each year worldwide with approximately 1.9 million children below five years of age dying due to diarrhea. There are many known causes of diarrhea, namely due to viral, bacterial, or parasitic infections. Some of the serious diseases that cause diarrhea include, inflammatory bowel disease like Crohn's disease, Celiac disease, cancer, among others.
The primary line of treatment of diarrhea includes rehydration with oral rehydration solution or salts (ORS). Over the counter antidiarrheal medications that comprise of Imodium and Loperamide, which are antimotility drugs are usually prescribed to decrease stool passage. The patient is prescribed medications for the treatment of the infection once the cause of diarrhea is diagnosed.
Several research organizations and governments institutes combined with pharmaceutical companies are conducting clinical trials to understand various therapeutic modes to treat and prevent diarrhea. For instance, Boston Pharmaceuticals is studying the safety, tolerability, and efficacy of BOS-589 in treatment of diarrhea caused by Irritable Bowel Syndrome (IBS-D) and is currently in phase 2 clinical trial.
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As of 2018, approximately 60% of the pipeline candidates for diarrhea are in the phase-2 and phase-3 clinical stage. More than half of the studies are sponsored by research institutes and government organizations.
The report on ‘Diarrhea – Pipeline Review, 2019’ provides a comprehensive overview of the drugs that are in the R&D pipeline by indication or molecule for diarrhea. The report provides a thorough analysis of the distribution of the pipeline products by clinical trial stage, indication, company, therapy area and details such as clinical trial stage, sponsor, description on every product in the pipeline. Products in the preclinical and clinical stage along with dormant & discontinued pipeline candidates are included in the report. The report also covers additional insights such as epidemiology overview and current market scenario for diarrhea.
The report on ‘Diarrhea – Pipeline Review, 2019’, which is built by following a robust research methodology involving primary interviews and desk research, provides a complete overview of the R&D activity and pipeline products to assist companies in developing growth strategies and identifying emerging players.
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