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Bone Graft Substitutes Market to Reach USD 3.93 Billion by 2027: Rising Application in Dental Procedures to Aid in Expansion

June 29, 2020 | Healthcare

The global bone graft substitutes market size is poised to reach USD 3.93 billion by 2027 attributed to the increasing incidence of tooth decay or weak tooth structure. A rise in the application of bone graft for tooth replacement, jawbone strengthening, dental implants, and other dentistry-related techniques are aiding to the expansion of this market. A recent report by Fortune Business Insights, titled, “Bone Graft Substitutes Market Size, Share & Industry Analysis, By Type (Autograft, Allograft, Demineralized bone matrix (DBM), Synthetic, Xenograft), By Application (Spinal Fusion, Joint Reconstruction, Foot & Ankle, Others), By End User (Hospitals, Specialty Clinics) and Regional Forecasts, 2020-2027,” states that the market value was USD 3.18 billion in 2019 and is likely to rise at a CAGR of 5.1% between 2020 to 2027.

Japan Hosts Launch of First DBM Product by Medtronic for Orthopedic Treatment

Medtronic Plc., a leading company dealing with medical device manufacturing, announced the launch of a new DMB bone grafting product called Grafton (TM) in Japan in February 2019. This new demineralized bone matrix (DBM) product is the first of its kind and the only one available in Japan. The Grafton was approved by the Pharmaceuticals and Medical Devices Agency (PMDA) in August 2018. This product is a bone graft extender and helps to fill the gaps found in the pelvis, spine, or other extremities. The senior VP and President of the Spine Division, Medtronic, states, “The Grafton DBM will help surgeons to suffice to the demand of each patient and their unique medical demands, further attributed to its high osteoinductivity and an unmatched combination of biologic therapies. We are creating three forms of Grafton for ailing to different needs of orthopedic patients. These include Grafton Matrix Strip, Grafton Matrix, and Grafton Putty.”

This product has been utilized for more than a billion procedures around the world. It is commercially available in Latin America, the Middle East, Europe, Korea, Australia, the U.S., and other parts. Such initiatives are likely to bode well for this market in the coming years.

To get a detailed report summary and research scope of this market, click here:


Increasing Investments in Research and Development of Novel Bone Grafts to Propel Growth

The increasing number of accidents and trauma cases are the key factors promoting the bone graft substitutes market growth. Additionally, the growing incidence of spinal cord injury is also adding impetus to the market. The increasing investment in research and development of new bone grafts is expected to aid in the expansion of the market.

On the flip side, certain side effects of bone grafting such as infection, blood clot, nerve damage, infection derived from the donor, and others may pose a significant hindrance to the market. Nevertheless, the increasing geriatric population and their vulnerability to various disorders of the joints and bones will help the market for bone graft substitutes to exhibit lucrative growth opportunities in the coming years.

Players Emphasizing on Investing in Research and Development Activities to Strive for Lion’s Share

The presence of many players has resulted in a fragmented nature of the market for bone graft substitutes. Most companies are engaging in merger and acquisition, joint ventures, contracts and agreements, and other collaborative efforts to gain a significant position in the market. Others are investing massively on research and development of novel bone grafting techniques to attract high revenues to their brand name, thereby contributing to the overall growth of the market.

Key Industry Developments of Market Include:

  • February 2014 – Puros Demineralized Bone Matrix Strip and Block were launched by Zimmer Spine Inc. for stimulating natural bone formation processes in spinal surgeries.

  • December 2016 – Xpand Biotechnology B.V., a company in the field of orthobiologics, was acquired by Kuros Biosciences Ltd. for manufacturing bone grafts.

  • March 2019 – BONIFY, a product line of the demineralized bone matrix, was announced by BONESUPPORTTM for expanding the product polio of the company in the U.S.

List of Prominent Players in the Market for Bone Graft Substitutes Include:

  • Medtronic Plc.

  • DePuy Synthes

  • Globus Medical

  • Seaspine

  • MTF Biologics

  • Stryker

  • Integra LifeSciences

  • Orthofix

  • Zimmer Biomet

  • Nuvasive

  • Aesculap Inc (B.Braun)

  • Alphatec

  • Other Players

Further Report Findings:

  • North America earned USD 1.27 billion in 2019 and emerged dominant in the market for bone graft substitutes. This is attributable to the presence of significant players in the region and an increasing number of trauma cases.

  • Based on segmentation by type, the allograft segment earned 25.67% market share. However, the demineralized bone matrix (DBM) segment is likely to show a progressive growth rate on account of the minimal chances of disease transmission or immune-mediated rejection and promotion of bone-growth at surface level.

The Global Market is categorized into:



Study Period


Base Year


Forecast Period


Historical Period



  Value (USD billion)


By Type

  • Autograft

  • Allograft

  • Demineralized bone matrix (DBM)

  • Synthetic

  • Xenograft

By Application

  • Spinal Fusion

  • Joint Reconstruction

  • Foot & Ankle

  • Others

By End User

  • Hospitals

  • Specialty Clinics

By Geography

  • North America (the U.S. and Canada)

  • Europe (U.K., Germany, France, Italy, Spain, Scandinavia, and the Rest of Europe)

  • Asia-Pacific (Japan, China, India, Australia, Southeast Asia, and the Rest of Asia- Pacific)

  • Latin America (Brazil, Mexico, and the Rest of Latin America)

  • The Middle East & Africa (South Africa, GCC and the Rest of the Middle East & Africa)

Bone Graft Substitutes Market
  • PDF
  • 2019
  • 2016-2018
  • 160


  • 4850

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