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Bone Graft Substitutes Market Size, Share & Industry Analysis, By Type (Autograft, Allograft, Demineralized bone matrix (DBM), Synthetic, Xenograft), By Application (Spinal Fusion, Joint Reconstruction, Foot & Ankle, Others), By End User (Hospitals, Specialty Clinics) and Regional Forecast, 2020-2027

Region : Global | Format: PDF | Report ID: FBI103106



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The global bone graft substitutes market size stood at USD 3.18 billion in 2019 and is expected to reach USD 3.93 billion by 2027, exhibiting a CAGR of 5.1% during the forecast period.

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Bone grafting is a surgical procedure that restores a misplaced bone with bone grafts or its substitutes to fix bone fractures that pose a significant health risk to the patient. Bone grafting is done for compound fractures. Bone grafts are majorly used in spinal fusion procedures. Physicians can use bone grafts to stabilize a corrected spinal deformity, prevent motion between two or more vertebral bodies, or repair spinal fractures. Bone graft doesn't fuse or heal the spine immediately but it offers a scaffold or foundation for the patient's body to grow a new bone. Increasing incidence of trauma cases across the globe is one of the major factors propelling the bone graft substitutes market growth. Moreover, increasing research and development activities, coupled with various nonprofit organizations sparing funds for clinical research is another significant factor adding impetus to the market.


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Rising Application for Dental Procedures will Bolster Growth

The rising demand for bone graft substitute in dental procedures is one of the major growth driving factors. The bone around the area of a fallen tooth starts to decay in some cases, which ultimately leads to severe gum infections, thereby causing weak teeth structure. Fortunately, to tackle such issues novel bone grafting techniques were introduced. This can benefit both appearance and health by allowing more effective tooth replacement, strengthening jawbone, thereby increasing support to facial features. Bone grafts are used in dentistry to accomplish tooth extractions, dental implants, and treat severe periodontal disorders. Several bone graft substitutes are developed to improve dentistry such as demineralized bone grafts, synthetic grafts and few others. Hence, such novel developments will suggest a positive growth trajectory for the market during the analysis period.


Increasing Cases of Spinal Surgeries Worldwide will Facilitate Market Growth

Spinal fusion is a surgical procedure for correcting issues with the small bones in the vertebrae. The general approach is to fuse two or more vertebrae together and turn them into a solid, single bone. It is majorly done with the help of bone graft substitutes through bone grafting. As per the Centers for Disease Control and Prevention (CDC), in 2017, around 30% of the adult population and more than 60% of the geriatric population is affected by spinal deformities. Moreover, as per estimations, there were around 480,000 spinal surgeries performed in the U.S. Hence, the increasing cases of spinal surgeries has augmented the growth of the market across the forecast period. Additionally, the increasing cases of trauma has led to the growth of such procedures, thereby propelling growth.

Rising Investments and Research Funding will Bolster Growth

Increasing investments and funds to support the market is one of the major factors aiding to the expansion of the market. Several non-profit and other government organizations are sparing funds for research and clinical trial of bone graft substitutes for efficient outcomes in the orthopedic surgeries. For instance, In February 2020, MTF Biologics, a worldwide nonprofit organization focused on organ and tissue donation, research, and transplantation, has awarded USD 1.8 billion in funding through its 2019 Extramural Research Grants Program to 12 researchers across the U.S. Since 1987, the organization has offered around USD 55 Mn as funds to biological reconstruction and advance allograft transplantation science. Such initiatives are expected to support the market and generate significant revenues in the coming years.


Side Effects Associated with Bone Graft Substitutes Might Restrict Growth  

Despite the increasing demand for treatment procedures, the side effects associated with the use of bone graft substitutes may hinder growth up to a certain extent. For instance, some risks associated with bone grafting are infection, blood clot, bleeding, and nerve damage, infection from the donated bone and complications from anesthesia. Hence such associated side effects of bone grafts are one of the preliminary factors restricting growth.


By Type Analysis

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Increasing Demand for Demineralized Bone Matrix (DBM) will Stimulate Growth

Based on product type, the market is segmented into autograft, allograft, demineralized bone matrix (DBM), synthetic, and xenograft. The DBM segment is anticipated to witness lucrative growth across the analysis period owing to the increasing demand for various forms of DBM products such as putty, granules and gel. DBM is a specific bone graft developed by acid extraction of allograft and contains non-collagenous proteins, collagen, and a variable number of osteoinductive growth factors (IGF, BMP, TGF-β) depending on the manufacturing process. DBM is considered to be an ideal choice in terms of bone graft substitutes owing to its several associated benefits. The ideal DBM has minimum chances of immune-mediated rejection or disease transmission and it promotes surface-level bone growth. Hence, such associated benefits boosted the product demand, thereby propelling the market growth.

The synthetic segment earned a significant revenue in 2019 and is likely to continue doing so in the forecast period. This is attributable to the increasing approval of synthetic bone grafts for various orthopedic procedures. The synthetic bone grafts can offer some benefits including strong resemblance to human bones, free risk of infection, better support of patient's mobilization, reliable availability and quality, shorter postoperative care, and more predictable bone growth. Hence, such associated benefits are likely to boost the growth of this segment across the forecast period.

By Application Analysis

Increasing Incidence of Spinal Surgeries to Aid Dominance of Segment

Based on application, the market is segmented into spinal fusion, joint reconstruction, foot & ankle, and others. The spinal fusion segment is expected to dominate the market attributed to the increasing number of spinal surgeries across the globe. The increasing incidence of trauma cases is one of the major factors leading to the growing rate of spinal surgeries. For instance, as per the American Association for the Surgery of Trauma, every year in the U.S., injury accounts for over 150,000 deaths and over 3 billion non-fatal injuries. Such factors are significantly contributing to the growth of the market.

The joint reconstruction segment, on the other hand, is estimated to witness stable growth during the analysis period. Increasing number of joint reconstruction surgeries across the globe is one of the major factors augmenting segmental growth. For instance, as per the National Institute of Health, there are approximately 700,000 joint replacement procedures done every year in the U.S.

By End User Analysis

Rising Number of Strategic Partnership among Hospitals and Manufacturers will Propel Segment Growth

By end-user, the global market is classified into hospitals and specialty clinics. The hospitals segment held the major bone graft substitutes market share attributed to factors such as increasing number of private and public hospitals, coupled with the growing number of orthopedic surgeons across the globe. Moreover, the presence of state-of-the-art facilities in hospital settings required for a bone surgery is another important factor propelling the growth of this segment. Moreover, increasing strategic partnership with several private and public companies to acquire various bone graft products is another significant factor augmenting growth of this segment across the projection period.

Specialty clinics on the other hand, are forecasted to witness a stable growth during the analysis period. Positive growth is attributable to the increasing number of patient pool visiting such medical settings to opt for treatment. Moreover, the rising awareness among people about several benefits of bone grafting is another important factor drawing patient pool towards these facilities, thereby augmenting the growth of this segment. 


North America Bone Graft Substitutes Market Size, 2016-2027 (USD Billion)

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Geographically, this market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. Among these, North America held the lion’s share with revenue of USD 1.27  billion earned in 2019. High growth is owing to the growing incidence of trauma cases leading to a rise in the number of spinal and joint reconstruction surgeries, thereby augmenting the market in this region. Moreover, the presence of prominent players operating in the U.S. is another significant factor propelling the regional growth. For instance, MTF biologics is one of the top manufacturers and operates majorly in the U.S. market. Furthermore, the presence of several orthopedic clinics in the region is another important factor contributing to the regional growth of the market. Asia Pacific on the other hand is forecasted to witness tremendous growth in the market attributable to the increasing healthcare expenditure of the region. Moreover, increasing number of accidents and trauma cases, coupled with growing medical tourism in the South East Asian countries is another strong reason supporting the regional growth of the market. Also, rising number of the companies penetrating in the developing economies of Asia to capture untapped markets will further boost the market in the region. The Middle East & Africa market on the other hand is estimated to witness lucrative growth during the analysis period owing to the increasing number of orthopedic procedures being conducted in the region. Furthermore, the markets in Saudi Arabia and UAE has tremendous growth potential owing to rising medical tourism in these countries.


Core Focus on Research and Development Activities by Medtronic and MTF Biologics to Propel their Market Position.

The competitive landscape of this market is fragmented in nature. The market exhibits a low level of concentration, with no single-player holding the dominant share. This is majorly attributed to the plethora of products commercially available in several regions of the world.  

However, some players operating in this market are Medtronic, MTF Biologics, Integra, Zimmer Biomet, DePuy Synthes, Stryker, Nuvasive and few others. Among these, MTF Biologics is one of the top players devoted to constant rigorous research and development of the novel bone grafts substitutes. For instance, the organization has offered more than USD 50 billion funds to boost ongoing researches at research institutes and academic medical centers across the U.S. Hence, such diligent efforts assisted the organization to gain a strong foothold in the market.


  • Medtronic Plc

  • MTF Biologics

  • Zimmer Biomet

  • DePuy Synthes

  • Stryker

  • Nuvasive

  • Globus Medical

  • Integra LifeSciences

  • Aesculap Inc (B.Braun)

  • Seaspine

  • Orthofix Holdings

  • Alphatec

  • Others


  • March 2019 – BONESUPPORTTM, an emerging leader in orthobiologics, announced the launch of BONIFY, a demineralized bone matrix (DBM) product line, expanding the company’s product portfolio in the US market.

  • September 2018 – Baxter International Inc. announced U.S. Food and Drug Administration (FDA) clearance of Actifuse Flow Bone Graft Substitute for use in a variety of orthopedic surgical procedures.

  • February 2014 – Zimmer Spine Inc. announced the U.S. market launch of Puros Demineralized Bone Matrix Block and Strip, bone graft substitutes used to stimulate natural bone formation processes in spine surgical procedures.


The bone graft substitutes market research report provides a detailed analysis of the industry and focuses on key aspects such as novel product launch, leading market players, and others. Besides this, the report offers insights into the market, highlights key industry developments and current trends. In addition to the above mentioned factors, the report includes various factors that have contributed to the growth of the global market over the recent years. Moreover, the report will provide a   detailed product pricing analysis and insights on funding scenario pertaining to research and development of bone graft substitute.

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Report Scope & Segmentation



Study Period


Base Year


Forecast Period


Historical Period



  Value (USD billion)


By Type

  • Autograft

  • Allograft

  • Demineralized bone matrix (DBM)

  • Synthetic

  • Xenograft

By Application

  • Spinal Fusion

  • Joint Reconstruction

  • Foot & Ankle

  • Others

By End User

  • Hospitals

  • Specialty Clinics

By Geography

  • North America (the U.S. and Canada)

  • Europe (U.K., Germany, France, Italy, Spain, Scandinavia, and the Rest of Europe)

  • Asia-Pacific (Japan, China, India, Australia, Southeast Asia, and the Rest of Asia- Pacific)

  • Latin America (Brazil, Mexico, and the Rest of Latin America)

  • The Middle East & Africa (South Africa, GCC and the Rest of the Middle East & Africa)

Frequently Asked Questions

Fortune Business Insights says that the global market size was USD 3.18 billion in 2019 and is projected to reach USD 3.93 billion by 2027.

In 2019, the market value stood at USD 3.18 billion.

The market is growing at a CAGR of 5.1%, the market will exhibit stable growth during the forecast period (2020-2027).

Synthetic segment is expected to be the leading segment in the market during the forecast period.

Increasing incidence of trauma cases in several regions of the world is forecasted to boost the market.

Medtronic plc. is one of the leading players in the global market.

North America dominated the market share in 2019.

Bone Graft Substitutes Market Size, Share and Global Industry Trend Forecast till 2026
  • Jun, 2020
  • 2019
  • 2016-2018
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