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Bone Void Fillers Market Size, Share & Industry Analysis, By Type (Demineralized Bone Matrix (DBM), Collagen Matrix, Calcium Sulfate, Tri-calcium Phosphate, and Others), By Form (Gel, Granules, Paste, Putty, and Others), By End User (Hospitals, Specialty Clinics and Others), and Regional Forecast, 2020-2027

Region : Global | Format: PDF | Report ID: FBI101015



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The global bone void fillers market size stood at USD 2.80 billion in 2019 and is projected to reach USD 3.90 billion by 2027, exhibiting a CAGR of 5.4% during the forecast period.

Bone void fillers, which are used for the treatment and management of bone voids, caused several bone associated conditions such as fractures and traumas, bone infections (osteomyelitis), and bone tumors (malignant and benign). These products, especially the synthetic bone void fillers, are witnessing rapid and strong adoption rates, due to various associated advantages such as sterility, decreased risk of infections, and an infinite supply of raw materials. The market is expected to witness strong growth during the forecast period owing to the increasing prevalence of bone-associated diseases. Furthermore, increased clinical studies demonstrating the favorable treatment outcomes with these products, and the new regulatory approvals and subsequent launches of strong products will favor market growth. In terms of the recent COVID-19 pandemic, the market may suffer some growth limitations, as almost all elective and non-essential medical procedures were put on hold during this period.


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Increasing Adoption of Antibiotic Eluting Bone Void Fillers to Augment Market Growth

The key trends prevailing in this global market include the increasing adoption of antibiotic eluting bone void fillers. In these types of products, the material used in these fillers are mixed with antibiotics to further increase the treatment efficiency. This is primarily because these products are extensively used in the treatment of several bone-associated infections such as osteomyelitis and diabetic foot infections. For instance, the product portfolio of BONESUPPORT AB includes CERAMENT G and CERAMENT V, which are antibiotic eluting bone void fillers. These product offerings are showcasing strong market growth owing to their rising adoption as they are better equipped to deal with infections than normal products. This is projected to further propel the Bone Void Fillers market growth during the forecast period.


Increasing Prevalence of Bone Diseases & Other Associated Incidents to Fuel Demand

The most critical driver of this market is the increasing global prevalence of several bone diseases such as bone infections (osteomyelitis), bone tumors, and diabetic foot ulcers. For the appropriate treatment and management of such conditions, these fillers are necessary to be administered. Another critical need arises in the cases of fractures and traumas, wherein increasing incidences have been witnessed globally, and these factors are further expected to drive the global market demand extensively. For instance, according to research published in 2018 by companies such as BONESUPPORT AB, the incidence of diabetes is projected to increase by 55% over the next 20 years, which is further expected to contribute to a significant number of cases of diabetic foot infections. Since these products can better address the bone voids caused by diabetic foot infections, the demand for these product offerings is further expected to rise.

Even in the case of osteomyelitis (bone infections), these products serve as an indispensable option for the surgeons involved in the management and treatment of the disorder. This is particularly relevant as the fillers present more clinical treatment options to the surgeon. Moreover, some of the bone infections are found to be recurrent in terms of nature. This is anticipated to contribute to the substantive increase in the demand for the products, which aids in the effective management of the disorders and will create growth opportunities for the market. .

Increasing Number of Synthetic Product Launches to Drive the Market

Despite, the strong procedural volume and establishment of demineralized bone matrix (DBM) as a bone void filler, there has been an increasing adoption of synthetic products. Synthetic fillers include calcium sulfate and tri-calcium phosphate and have many advantages such as sterility and an infinite supply of raw materials. Hence, several key market players, established and emerging, are focusing their efforts on the development and marketing of these synthetic fillers. For instance, in April 2020, Biocomposites, a key emerging player, announced that they received the CE Mark in the European Union for their product offering of STIMULAN. Such strong product launches, coupled with increasing adoption of these synthetic products, is further expected to drive the market growth. 


Under Penetration of the Product and Certain Clinical Limitations to Restrain the Adoption

In the modern scenario, there is greater adoption of these products across the globe owing to the increasing prevalence of several bone-associated disorders and increasing awareness among the patients. Furthermore, in some of the cases, the autogenous and allograft bone transplantations are still considered the gold standard in procedures requiring these fillers. Such considerations have limited the adoption of these product offerings up to a significant extent and have led to the market being under penetration in some parts of the global market. Another, key restraining factor includes the clinical limitations associated with some of these products. These clinical limitations include poor resorbability, presence of animal or marine-derived components, variability in handling characteristics, and expensive costs. Such factors are expected to limit market growth in the forecast period.


By Type Analysis

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Demineralized Bone Matrix (DBM) Dominated the Global Market

Based on type, the global market is segmented into demineralized bone matrix (DBM), collagen matrix, calcium sulfate, tri-calcium phosphate, and others. The demineralized bone matrix (DBM) segment dominated the global market share in 2019. Some of the contributing reasons for this segment’s dominance include the advantages associated with demineralized bone matrix (DBM), and the high procedural volume for demineralized bone matrix (DBM) in the key territories of the United States, and key countries in Europe.

The calcium sulfate and the tri-calcium phosphate segments are anticipated to register the highest CAGR due to the increasing number of product launches and the increasing adoption of synthetic fillers of which these two segments are part. The collagen matrix is estimated to register a lower CAGR due to a limited number of product offerings attributed to this segment, and a comparatively lesser number of product launches in this segment.

By Form Analysis

Large Number of Bone Void Fillers in Putty Form to Aid Dominance of the Segment

In terms of segmentation by form, the market comprises of gel, granules, paste, putty, and others. The putty form is expected to be the most dominant segment owing to a large number of product availability in this form. For instance, a large number of demineralized bone matrix (DBM) fillers are available in the form of putty. Furthermore, this trend is expected to prevail in the forecast period and is one of the key reasons for the dominance of the putty segment. One of the other common forms of these product offerings is the paste and granules forms. Moreover, the recent product launches in the paste segment are expected to contribute to the growth of the segment.

The other segment is the gel segment, which is expected to register a lower CAGR owing to the lack of product offerings and new product launches in the segment that is likely to limit the growth of this segment.

By End User Analysis

Dependence on Hospitals for Administration of Bone Void Fillers to Enable Dominance of the Segment

In terms of end user, the market is segmented into hospitals, specialty clinics, and others. The key and contributing reasons for the dominance of this segment include the dependence on hospitals for critical orthopedic procedures such as the administration of these products in bone voids. This is owing to the global scenario, wherein, there is a large proportion of hospitals compared to other medical institutions. Furthermore, the medical professionals in hospitals ensure proper adherence to the guidelines for administration of bone void fillers.  Moreover, in emerging regions, government hospitals may also provide subsidized treatments for such critical procedures.

The specialty clinics are expected to grow at the highest CAGR backed by growing demand for specialized care in orthopedics, which has led to the growth in the number of specialty clinics, especially in the developed regions. The others segment is anticipated to grow at a lower CAGR, though, this segment has some key medical institutions such as ambulatory surgery centers.


North America Bone Void Fillers Market Size, 2019 (USD Billion)

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In terms of region, the global market is segmented into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa. The most dominant region in the market is likely to be the North America. Furthermore, the revenue in the region stood at 1.31 billion in 2019. This is ascribable to factors such as strong pricing of these products in the region, strong procedural volume, and the high adoption of technologically advanced products. The aforementioned factors, coupled with upcoming regulatory launches, strong prevalence of bone associated diseases in the region, and the new product launches, are further enabling this region’s dominance in the global market. The second-most leading market is the European market. Furthermore, key factors driving the strong growth of the market includes the presence of emerging competitors such as BONESUPPORT AB, coupled with the increasing adoption of advanced products such as antibiotic eluting bone void fillers. The Asia Pacific region is expected to register the highest CAGR during the forecast period. The critical reasons for the strong growth of this region includes the under-tapped potential of the region, the strong patient population base, and increasing awareness of bone associated diseases leading to a greater demand for these product offerings. The region of Latin America is currently registering a lower growth compared to other key regions. However, improving factors such as increased awareness and growing healthcare expenditure coupled with increasing incidences of traumas, are expected to drive the growth during the forecast period. The region of the Middle East & Africa is currently in a nascent stage. However, improvement in parameters such as increased healthcare infrastructure and increasing adoption of advanced these product offerings in future is expected to contribute to the region’s growth in the forecast period.


Strong and Diversified Product Portfolio of Zimmer Biomet and Stryker to Enable Dominant Market Position These Companies Maintain Dominant Market Position

In terms of the competitive landscape, the global market depicts a monopolistic competition structure, where there is a presence of a number of companies. The competition landscape comprises of numerous companies, which includes established and emerging market players with cutting edge and advanced product offerings. However, in terms of market share, two prominent companies, Zimmer Biomet and Stryker, are dominating the market owing to their strong product portfolios and keen focus of their products on the key application areas such as spine, and trauma. For instance, Zimmer Biomet’s product offering of CopiOs Bone Void Filler, has a strong focus and application in terms of spine procedures. On the other hand, Stryker also has a number of strong product offerings, which includes the Vitoss Synthetic Bone Graft, a product of high caliber and possessing of the ideal bone void filler characteristics of osteoconductivity and osteoinductivity.

However, one of the key trends prevailing in this competitive scenario is the emergence of new market players, which includes BONESUPPORT AB, Biocomposites, and Pacific Bioceramics. These companies are focusing their efforts on the diversification and strengthening of their product portfolios. Moreover, they are directing their focus on regulatory approvals in key market and subsequent launches of technologically advanced products. Such trends and factors are expected to help these companies increase their market share substantially during the forecast period.



  • Wright Medical Group N.V.

  • DePuy Synthes Companies

  • Stryker

  • Arthrex, Inc.

  • Biocomposites

  • Zimmer Biomet

  • Collagen Matrix, Inc.

  • Pacific Bioceramics

  • Others


  • April 2020 – BONESUPPORT AB announced that the De Novo application for their product offering of CERAMENT G has been submitted to the U.S. FDA for market approval for the indication of osteomyelitis

  • April 2020 – Biocomposites announced that their product offering of STIMULAN, received a new CE Mark from the European Union for the purpose of mixing antibiotics such as vancomycin, gentamicin and tobramycin, which can be used a treatment option in the management of infected bone and soft tissue

  • March 2020 – Biocomposites announced the United States launch of their product offering of STIMULAN Rapid Cure 3cc, which can be used in the targeting of smaller voids in cases of trauma, foot and ankle, and orthopedic surgery.


An Infographic Representation of Bone Void Fillers Market

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The market research report provides a detailed analysis of the market and focuses on key aspects such as epidemiology of bone tumors, new product launches - key players, overview of guidelines for the product, and key industry developments (mergers, acquisitions, and partnerships, etc.). Besides this, the report offers insights into the market trends and highlights other market dynamics. In addition to the aforementioned factors, the report encompasses several factors that have contributed to the growth of the market over the recent years.

Report Scope & Segmentation



Study Period


Base Year


Forecast Period


Historical Period



  Value (USD billion)


By Type

  • Demineralized Bone Matrix (DBM)

  • Collagen Matrix

  • Calcium Sulfate

  • Tri-calcium Phosphate

  • Others

By Form

  • Gel

  • Granules

  • Paste

  • Putty

  • Others

By End User

  • Hospitals

  • Specialty Clinics

  • Others

By Geography

  • North America (U.S. and Canada)

  • Europe (Germany, U.K., France, Italy, Spain, Scandinavia, and Rest of Europe)

  • Asia-Pacific (China, India, Japan, Australia, Southeast Asia, and Rest of Asia-Pacific)

  • Latin America (Brazil, Mexico, and Rest of Latin America)

  • The Middle East & Africa (South Africa, GCC Countries, and Rest of Middle East & Africa)

Frequently Asked Questions

Fortune Business Insights says that the global market size was USD 2.80 billion in 2019 and is projected to reach USD 3.90 billion by 2027.

In 2019, the market value stood at USD 2.80 billion.

Growing at a CAGR of 5.4%, the market will exhibit steady growth in the forecast period (2020-2027).

Demineralized bone matrix (DBM) segment is expected to be the leading segment in this market during the forecast period.

Anticipated introduction of more technologically advanced products in the market, coupled with increasing prevalence of bone diseases such as osteomyelitis and bone tumors, is fueling the demand for the market.

Zimmer Biomet and Stryker are the leading players in the global market.

North America dominated the market share in 2019.

Growing R&D and clinical trials by market players is leading to the development of advanced and efficient bone void fillers, coupled with increasing application areas for the product is driving the adoption.

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Bone Void Fillers Market Size, Share and Global Industry Trend Forecast till 2026
  • Jun, 2020
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