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Demineralized Bone Matrix (DBM) Market Size, Share & COVID-19 Impact Analysis, By Product Type (Gel, Putty, and Others), By Application (Dental, Craniomaxillofacial, Spinal Fusion, Long Bone Procedures, Joint Reconstruction, and Other Applications), By End User (Hospital, Specialty Clinics, and Others) and Regional Forecast, 2021-2028

Region : Global | Format: PDF | Report ID: FBI105449



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The global demineralized bone matrix (DBM) market size was USD 594.5 million in 2020. The global impact of COVID-19 has been unprecedented and staggering, with demineralized bone matrix products witnessing a negative impact on demand across all regions amid the pandemic. Based on our analysis, the global market exhibited a lower growth of -7.2% in 2020 as compared to the average year-on-year growth during 2017-2019. The market is projected to grow from USD 624.2 million in 2021 to USD 838.9 million in 2028 at a CAGR of 4.3% during the 2021-2028 period. The rise in CAGR is attributable to this market’s demand and growth returning to pre-pandemic levels once the pandemic is over.

A demineralized bone matrix is a form of allograft utilized in bone defects and spinal fusion. In this process the removal of the bone mineral exposing more biologically active bone morphogenetic proteins (BMP). These BMP growth factors modify the variation of progenitor cells into osteoprogenitor cells, which are responsible for cartilage and bone formation. These bone solutions are used to support and repair bones that are fractured due to trauma, helping in bone and cartilage formation. According to the National Safety Council, in 2019, there were an estimated 48.3 million injuries in the U.S. alone. The growing number of trauma surgery, and spine surgery is leading to an increasing number of patients undergoing bone treatments. This is driving the demand for DBM products in various healthcare settings globally.

Increasing investments by key players in research & development to engineer new products and to discover new applications of existing products are expected to boost the adoption of demineralized bone matrices in the coming future. For instance, in November 2020, SeaSpine conducted a study that demonstrated the company’s product, OsteoStrand Plus, was better than cellular bone matrix (CBM) products.

Suspension of Orthopedic Procedures amid the COVID-19 Pandemic to Negatively Impact the Market

The cancellation of non-emergency orthopedic procedures in several countries due to government and healthcare authorities' lockdown restrictions is anticipated to hamper market growth up to a certain extent. Additionally, many hospitals have been converted into COVID-19 isolation and treatment centers, which have led to the suspension of elective surgeries in various regions around the world. For instance, in early 2020, elective surgery rates declined by 85.0% to 90.0% in China and Italy. Moreover, similar impacts were observed in the U.S. and other European countries.

However, as countries across the world are cautiously reopening, the global market has witnessed the trend of a robust sales rebound. This is attributable to the gradual reopening of orthopedic practices worldwide. Overall, the COVID-19 pandemic is expected to exert a limited negative impact on the market's growth. For instance, Medtronic Plc sales from May 2020 to July 2020 were USD 6,507 million, and from August 2020 to October 2020 they stood at USD 7,647 million.


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Rising Incidence of Orthopedic Disorders to Augment Market Growth

The prevalence of orthopedic disorders is increasing at a significant rate. For instance, according to the World Health Organization (WHO), approximately 1.71 billion people worldwide are suffering from some form of musculoskeletal condition. Furthermore, research has shown that osteoporosis and fragility fractures represent a costly human and socioeconomic burden in all regions of the world. According to the International Osteoporosis Foundation, worldwide, osteoporosis causes more than 8.9 million fractures annually. Thus, these products are extensively used for the surgery and treatment of osteoporosis and fragility fractures. This factor presents an enormous growth opportunity for new entrants and established players to expand their footprint in this market and launch new products to cater to the increasing demand for DBM products.

Additionally, the aging population is also a significant factor as older persons are more susceptible to orthopedic diseases such as osteoarthritis, fractures, dislocations, and osteoporosis. According to the United Nations, in 2019, 1 in 11 people in the world will be over the age of 65 and this number is anticipated to increase to 1 in 6 people by 2050. This is projected to further propel the global market during the forecast period.


Increasing Number of Spinal Fusion and Dental Surgeries to Fuel Demand

The rising number of spinal fusion surgeries is fueling the demand for demineralized bone matrix products globally. For instance, according to StatPearls Publishing, the incidence of a herniated disc is about 5 to 20 cases per 1,000 adults annually. It is most common in people in their third to the fifth decade of life. This factor is likely to increase the demand for spinal fusion surgeries, which in turn is anticipated to surge the demand for DBM solutions.

Additionally, the significant rise in dental surgeries is also expected to boost demand for DBM as these products are important tools, which provide support in dental implant procedures. According to the FDI World Dental Federation, oral diseases affect nearly 3.5 billion people worldwide, and the organization estimated that 2.3 billion people globally suffer from tooth decay (dental caries). Furthermore, the organization stated that gum (periodontal) disease is among humanity’s most common diseases, affecting up to 50% of the global population.

A rising number of dental diseases cause permanent loss of teeth, which eventually fuels the demand for these products in dental implant surgeries. Such factors are expected to drive the market in the forthcoming years.


High Cost of DBM to Restrict Market Growth in Emerging Economies

Demineralized bone matrix products have witnessed significant developments in the past decade, including design modifications, among others. However, the cost of bone grafting procedures and DBM is considerably high due to the rigorous manufacturing process and the high cost associated with the storage of the product in a sterile environment. Thus, these factors increase the overall cost of DBM products, which is anticipated to hinder market growth during the forecast period. For instance, in the U.S., the average cost of dental bone graft can vary between USD 400 and USD 1,200 for end-users. Furthermore, limited reimbursement for dental bone graft surgeries has also been a restricting factor, resulting in the lower adoption of these products. Many insurance systems, including Medicare, do not cover dental bone grafts in most circumstances. Thus, the above factors have been responsible for the relatively limited adoption of products in several countries and regions.


By Product Type Analysis

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Putty Segment to Dominate Backed by Advent of Unique Products

Based on product type, the global market is segmented into gel, putty, and others.

The putty segment held the dominant share of the global market in 2020 due to the surge in the adoption of these advanced products to support the treatment of several orthopedic and dental disorders. Moreover, the increased prevalence of several orthopedic diseases is also a contributing reason for the segment’s dominance.

The gel segment is anticipated to expand at a comparatively higher CAGR during the forecast period. This is due to the rising craniomaxillofacial, aesthetic, and trauma surgeries that require demineralized bone matrix products, and the excellent biocompatible nature offered by gel-based products. Distinct advantages over putty are leading to a higher demand for gel-based products and this subsequently is driving the growth of the segment.

By Application Analysis

Increasing Number of Spinal Procedures to Ensure Higher Share of the Spinal Fusion Segment 

On the basis of application, the market can be segmented into dental, craniomaxillofacial, spinal fusion, long bone procedures, joint reconstruction, and other applications.

The spinal fusion segment held the dominating share in 2020 due to the surge in the number of spine surgeries or fusion procedures among patients with spinal disorders. Additionally, an increasing number of spinal cord injuries is leading to an upsurge in the demand for advanced spinal fusion procedures. According to World Health Organization (WHO), every year, between 250,000 and 500,000 people suffer a spinal cord injury (SCI) around the world.

The dental application segment is expected to grow at a significant CAGR during the forecast period. The growth rate is attributed to the dental surgeon's high preference for demineralized bone matrix products for dental surgeries. Furthermore, the rising number of training sessions undertaken for dental practitioners by prominent companies to enhance awareness about DBM is expected to lead to this segment’s high growth. Moreover, the availability of highly skilled dentists would also contribute to the development of this segment.

By End-User Analysis

Higher Procedural Volume at Hospitals to Enable Dominance of Segment

Among end-users, the market segments include hospitals, specialty clinics, and others. The hospital segment dominated the market in 2020 owing to the higher number of bone graft procedures taking place in hospitals for orthopedic and dental procedures. Additionally, adequate reimbursement policies are awarded by hospitals in developed and emerging countries.

Hospitals are also equipped with technologically advanced instruments and systems to perform surgeries. Hence, the hospital segment is expected to grow at a higher CAGR owing to the rising shift of patients preferring hospitals for bone graft procedures. Additionally, with an increasing number of hospitals in developed and emerging countries and the growing availability of numerous medical services in these facilities, the segment is likely to grow astonishingly.


North America Demineralized Bone Matrix (DBM) Market Size, 2020 (USD Million)

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On the basis of region, the global market can be segmented into the key regions of North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

The market value in North America stood at USD 301.3 million in 2020 and the region is anticipated to continue to dominate the demineralized bone matrix market share during the forecast period. Some of the prominent factors contributing to the region’s leading share include the direct presence of major companies in the region, such as Johnson & Johnson (DePuy Synthes), Zimmer Biomet, and Stryker, along with rising R&D investments by these key players.

Other contributing factors include the strong adoption of technologically advanced products by medical service providers in the region. Furthermore, the strong demand for these products due to the augmented awareness associated with these products and new advanced products launched in the region will boost market growth in the North America region during the forecast period. For instance, in July 2020, Spine Wave, Inc. launched Tempest allograft bone matrix to enter into the spinal biologics market. This reinforced the company’s position in the DBM market.

Europe is estimated to be the second-most dominant region in terms of market share. Europe holds a significant share due to the increasing healthcare expenditure, well-established health infrastructure, and the presence of a large pool of patients suffering from orthopedic disorders.

The Asia Pacific demineralized bone matrix market is estimated to grow at the highest CAGR, especially in developing countries such as China, and India. For instance, in February 2019, Medtronic launched ‘Grafton’ demineralized bone grafting product for spine and orthopedic procedures in Japan. This product became Japan's First DBM bone grafting product for spine and orthopedic procedures. This launch expanded the company’s presence and strengthened its market position in Japan.

Improvements in healthcare expenditure in Latin America and the Middle East & Africa are expected to lead to future growth prospects.


Medtronic, Johnson & Johnson, Zimmer Biomet, and Stryker are Key Players in the Market

The competitive landscape of this market is fragmented, with players like Medtronic plc, Johnson & Johnson, Zimmer Biomet, and Stryker accounting for a significant share in 2020. The top market players are focusing on strategies such as acquisitions, collaborations, and new product developments and launches to strengthen their market position globally. For instance, in November 2020, Stryker completed the previously announced acquisition of Wright Medical Group N.V. This acquisition expanded the company’s ortho biologics product portfolio and reinforced the company’s global market position.

Other players with a significant presence in the global market include SeaSpine, Xtant Medical, RTI Surgical, HansBioMed, Arthrex GmbH, and Exactech, Inc. These companies are expected to focus on new product introductions to increase their market share during the forecast period.


  • Medtronic plc (Dublin, Ireland)

  • Johnson & Johnson (DePuy Synthes) (New Jersey, United States)

  • Zimmer Biomet (Indiana, United States)

  • Stryker (Michigan, United States)

  • SeaSpine (California, United States)

  • Xtant Medical (Montana, United States)

  • RTI Surgical (Illinois, United States)

  • HansBioMed (Seoul, South Korea)

  • Arthrex GmbH (Florida, United States)

  • Exactech, Inc. (Florida, United States)


  • July 2021 - RTI Surgical, a prominent surgical implant company announced a strategic partnership with Exactech associated with the development and supply of biologic bone substitutes. As part of this partnership, the company has acquired Exactech’s Optecure, a demineralized bone matrix used as a bone graft extender in the pelvis, and extremities

  • February 2021 - Kolosis BIO, LLC announced a collaboration with MTF Biologics (MTF). Both companies launched Kore Fiber, an exclusively processed demineralized cortical fiber allograft, which is an excellent option for bone grafting for Kolosis.

  • October 2020-Orthofix Medical Inc., a global medical device company announced the launch of O-GENESIS Graft Delivery System during the North American Spine Society (NASS) 2020 virtual annual meet. This system allows single-handed delivery to accommodate a versatile choice of other bone graft materials, such as fiberFUSE Demineralized Bone Matrix

  • July 2020 - Spine Wave announced the launch of Tempest Allograft Bone and entered into the spinal biologics market. It helped the company compete in the demineralized bone allograft segment and supplements its broad portfolio of innovative spine implant products.


An Infographic Representation of Demineralized Bone Matrix (DBM) Market

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The demineralized bone matrix (DBM) market research report provides detailed market analysis and focuses on key aspects such as an overview of the advanced product, the prevalence of orthopedic and dental disorders and key countries, and pricing analysis. Additionally, it includes an overview of reimbursement scenarios for surgical procedures, key industry developments such as mergers, partnerships, & acquisitions, the impact of COVID-19 on the market, and brand analysis. Besides these, the report offers insights into market trends and highlights key industry developments. In addition to the aforementioned factors, the report encompasses several factors that have contributed to the growth of the market over recent years. The report also covers regional analysis of different segments.

Report Scope & Segmentation



Study Period


Base Year


Forecast Period


Historical Period



  Value (USD Million)


Product Type, Application, End-User, and Geography

By Product Type

  • Gel

  • Putty

  • Others

By Application

  • Dental

  • Craniomaxillofacial

  • Spinal Fusion

  • Long Bone Procedures

  • Joint Reconstruction

  • Other Applications

By End-User

  • Hospital

  • Specialty Clinics

  • Others

By Geography

  • North America

    • By Product Type

    • By Application

    • By End-User

    • By Country

  • Europe

    • By Product Type

    • By Application

    • By End-User

    • By Country/ Sub-Region

  • Asia Pacific

    • By Product Type

    • By Application

    • By End-User

    • By Country/ Sub-Region

  • Latin America

    • By Product Type

    • By Application

    • By End-User

  • The Middle East & Africa

    • By Product Type

    • By Application

    • By End-User

Frequently Asked Questions

Fortune Business Insights says that the global market size was USD 594.5 million in 2020 and is projected to reach USD 838.9 million by 2028.

In 2020, the North America market value stood at USD 301.3 million.

Growing at a CAGR of 4.3%, the market will exhibit steady growth in the forecast period (2021-2028).

The putty segment is expected to be the leading segment in this market during the forecast period.

The rising incidence of orthopedic disorders and the increasing number of spinal fusion and dental surgeries are major factors driving the growth of the market.

Medtronic plc, Johnson & Johnson (DePuy Synthes), Zimmer Biomet, and Stryker are some of the major players in the global market.

North America dominated the market in 2020.

The surge in the adoption of advanced products to support the treatment of several orthopedic disorders and the rising number of craniomaxillofacial aesthetic and trauma surgeries that require DBM are expected to drive the adoption of these products.

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