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U.S. Bone Void Fillers Market Size, Share & COVID-19 Impact Analysis, By Type (Demineralized Bone Matrix, Collagen Matrix, Calcium Sulfate, Tri-calcium Phosphate, and Others), By Form (Gel, Granules, Paste, Putty, and Others), By Application (Spinal Fusion, Joint Reconstruction, Foot & Ankle, and Others), By End-user (Hospitals & Ambulatory Surgical Centers, Specialty Clinics, and Others), and Country Forecast, 2023-2030

Last Updated: June 03, 2024 | Format: PDF | Report ID: FBI106770



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The U.S. bone void fillers market size was valued at USD 1.34 billion in 2022. The market is projected to grow from USD 1.42 billion in 2023 to USD 2.22 billion by 2030, exhibiting a CAGR of 6.5% during the forecast period.

A bone void is a cavity in the bone that happens when the bone fails to heal itself. Bone void fillers are biological materials intended to fill the gaps in bones or bony voids of the spine, pelvis, and extremities. Hydroxyapatite, calcium sulfate, and calcium phosphate are some of the major materials used for filling bone voids.

The U.S. market is majorly driven by factors, such as rising incidence of injuries and fractures related to the spine and the growing prevalence of bone tumors & bone infections across the country. Moreover, the strong focus of manufacturers on the introduction of synthetic products due to the various benefits associated with them is expected to contribute to the market’s growth during the forecast timeframe.


COVID-19 Pandemic Had Negative Impact on Market Growth due to Declining Patient Visits

The COVID-19 pandemic impeded the demand for bone void fillers due to a decrease in patient volume. Key players operating in the market witnessed a considerable dip in their activities and earnings, largely due to the pandemic. The reallocation of healthcare resources, reduced number of patient visits, supply chain disruptions, and other key factors hampered the sales of bone void fillers in the U.S., mainly during the first six months of 2020. Based on revenue, the market observed an 8.9% dip in the same year.

For instance, Zimmer Biomet registered a decline of around 12% in its total revenue generated in 2020 compared to 2019. The Sports Medicine, Extremities and Trauma (S.E.T.) segment, which includes these fillers, witnessed a decrease of 7.7% in 2020 compared to 2019.

However, in 2021, the patient volume bounced back in the U.S. owing to higher vaccination coverage among the general population, implementation of COVID-19 guidelines in public places, and travel restrictions. These factors prompted an increase in the product demand. The revenue generated by Zimmer Biomet’s S.E.T. segment increased by 13.3% in 2021 compared to 2020. Therefore, the resumption of services positively influenced the demand for bone void fillers in 2021 and 2022.

U.S. Bone Void Fillers Market Trends

Strong Investments in Antibiotic-eluting Bone Void Fillers to Boost Market Growth

Total joint replacements, such as knee replacement and hip replacement need to be replaced as the prosthetic materials age with the patient. Factors such as bone infections, aseptic loosening, and aging of implants are increasing the rate of revision/replacement. The benefits provided by antibiotic-eluting fillers for revision surgeries are expected to boost market growth.

Additionally, the rising emphasis of leading companies on the launch of antibiotic-eluting products is expected to accelerate the U.S. bone void fillers market growth during the forecast timeframe.

  • In May 2022, the U.S. Food and Drug Administration (FDA) provided market authorization to BONESUPPORT AB for its antibiotic-eluting product, CERAMENT G, for bone infections (osteomyelitis).

Such a strong focus of market players on launching antibiotic-eluting products, coupled with the benefits offered by these products in total joint replacement surgeries, is expected to boost the U.S. market growth.

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U.S. Bone Void Fillers Market Growth Factors

Rising Prevalence of Spinal Disorders and Bone Tumors to Drive Market Growth

Spinal fusion is one of the most commonly performed spinal surgeries in the U.S. In spinal fusion, multiple vertebrae are fused together permanently to prevent movements between them. An increase in the number of spinal and orthopedic surgeries in the U.S. due to various bone fractures and sports injuries is driving the market’s growth.

  • For instance, according to a 2019 article by the National Center for Biotechnology Information, approximately 900,000 American adults undergo spine surgery annually. More than 75% of these surgeries are performed in the U.S.

Moreover, a large number of bone void fillers manufactured by companies operating in the U.S. market target spine applications.

Thus, the presence of multiple bone void filling materials for spine applications, coupled with the rising prevalence of bone related diseases, is expected to drive the U.S. market growth over the analysis period.

Introduction of Synthetic Bone Void Filling Materials to Contribute to Market Growth

Synthetic bone void fillers have several benefits over natural ones. These benefits include little or no risk of contamination, high success rate, and easy attainability and availability. Such benefits associated with synthetic products are increasing their demand among hospitals and ambulatory surgical centers in the U.S. Thus, owing to the increased demand for these products from various medical centers, manufacturers are focusing on the introduction of synthetic products across the country.

  • For instance, in February 2022, Orthofix Medical Inc. launched a synthetic bioactive bone graft solution called Opus BA. This product is used for cervical and lumbar spine fusion procedures and can also be used to fill bone voids or gaps in the skeletal system that are not intrinsic to the stability of the bone structure. These launches are expected to drive the market’s progress in the coming years.


Increasing Presence of Alternatives to Treat Bone Diseases Can Limit Market Progress

Autograft and allograft transplantations are some of the traditional treatments used to treat bone infections and filling bone voids. Despite a strong rise in the launch of synthetic products, a large population group in the U.S. still opts for allograft and autograft transplantations for their treatment.

  • For instance, according to information provided by RTI Surgical as an education service, in the U.S., approximately 1.75 million allografts are transplanted every year.

Moreover, several drawbacks associated with the use of synthetic bone void fillers, such as the inclusion of animal or marine-derived components, poor resorbability, and high cost can compel healthcare professionals to adopt traditional bone void filling treatments.

These disadvantages of synthetic products, coupled with the presence of alternative options for treating bone infections, are anticipated to limit the market’s growth to a certain extent.

U.S. Bone Void Fillers Market Segmentation Analysis

By Type Analysis

Utilization of Demineralized Bone Matrix Increased among Orthopedic Surgeons Due to Their Various Benefits

Based on type, the market is segmented into demineralized bone matrix, collagen matrix, calcium sulfate, tri-calcium phosphate, and others.

In 2022, the demineralized bone matrix segment held the largest share in the market. Various benefits associated with demineralized bone matrix, such as osteoinductivity, osteoconductivity, reduced morbidity, and proven clinical effectiveness, make it a preferred bone void filler, thereby propelling the segment’s growth.

The calcium sulfate segment accounted for a significant market share in 2022 and is expected to record a considerable CAGR during the forecast period. The segment’s growth is due to factors, such as the rising adoption of bone void filling materials containing calcium sulfate by the spine and orthopedic surgeons and the increasing launch of calcium sulfate-based products across the country.

  • To illustrate, in April 2019, orthopedic surgeons at the Richmond University Medical Center performed the first surgery using InterSep, which was manufactured by Pacific Bioceramics and distributed exclusively by Exactech.

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By Form Analysis

Increasing Research & Development Activities for Putty-based Products Increased Their Adoption

In terms of form, the market is divided into gel, putty, paste, granules, and others.

The putty segment accounted for the largest U.S. market share in 2022 and is estimated to record a substantial CAGR during the assessment period. The segment’s dominance is due to the increasing preference for putty-based bone void filling materials among orthopedic surgeons. Moreover, growing research and development activities to develop new products in putty form are expected to contribute to the dominance of this segment during the forecast period.

  • For instance, according to an article published by the NCBI in November 2020, a clinical study was funded by the North Dakota State University’s Department of Pharmaceutical Sciences to evaluate the efficacy of an Antibiotic-Releasing Bone Void Filling (ABVF) putty for the treatment of osteomyelitis. Therefore, rising funding for the research & development of putty-based products will drive the segment’s growth.

By Application Analysis

Surging Number of Total Joint Replacement Procedures Increased Product Use in Joint Reconstruction Surgeries

In terms of application, the market is segmented into joint reconstruction, spinal fusion, foot & ankle, and others.

In 2022, the joint reconstruction segment accounted for a considerable U.S. bone void fillers market share and is likely to register a moderate growth rate during the forecast period. An increasing number of total joint replacement procedures, such as knee and hip replacements, across the U.S. will contribute to the segment’s growth.

  • According to a June 2020 article by the American Academy of Orthopedic Surgeons, more than 450,000 hip replacements are done each year in the U.S. Such a large number of hip replacements is likely to surge the demand for bone void filling materials, thereby fueling the segment’s growth.

By End-user Analysis

Large Patient Footfall in Hospitals and Ambulatory Surgical Centers Drove Product Demand

Based on end-user, the market is divided into specialty clinics, hospitals & ambulatory surgical centers, and others.

The hospitals & ambulatory surgical centers segment dominated the market in 2022 and is anticipated to lead the market during the forecast period. The dominance of this segment is attributed to factors, such as the increasing number of patient admissions and surge in the number of spinal surgeries in these medical settings. Moreover, a significant number of hospitals and ambulatory surgical centers in the U.S. attract a large volume of patients for spinal and orthopedic surgeries, which, in turn, will drive the segment’s growth.

List of Key Companies in U.S. Bone Void Fillers Market

Stryker and Zimmer Biomet, with Robust Portfolio of Bone Void Fillers, Dominated Market in 2022

Stryker, Zimmer Biomet, and Medtronic plc are some of the key companies operating in the U.S. market.

In 2022, Stryker and Zimmer Biomet accounted for the largest share of the market. The dominance of these companies is due to their diversified product portfolios. Moreover, many of their bone void filling materials are used in spinal surgeries, which will further boost their dominance in the market.

Other small and medium-sized companies, including BONESUPPORT AB, Biocomposites Ltd., and Collagen Matrix, Inc. are focusing on increasing their presence in the market through various strategies, such as new product launches and investments in the research & development of novel bone void filling materials.

  • For instance, in 2020, BONESUPPORT AB announced that its CERAMENT BVF received the U.S. FDA’s approval for its use as a bone void filler.


  • Biocomposites (U.K.)

  • Zimmer Biomet (U.S.)

  • Arthrex, Inc. (U.S.)

  • Graftys (France)


  • Collagen Matrix, Inc. (U.S.)

  • Stryker (U.S.)

  • DePuy Synthes (U.S.)


  • June 2023: Anika Therapeutics, Inc. received an additional 510(k) clearance from the U.S. FDA for its Tactoset Injectable Bone Substitute. The product is used to fill various voids in the bone.

  • January 2022: Bone Solutions launched Mg OSTEOINJECT, an injectable bone filler in the U.S. The product is designed to promote bone repair and regeneration within micro fractures.

  • July 2021: Arthrex, Inc. announced an exclusive partnership with Celularity Inc. to distribute and commercialize the latter’s biomaterial products for sports medicine and orthopedic surgery.

  • December 2020: Collagen Matrix, Inc. acquired Sunstar’s GUIDOR synthetic bone graft & membrane portfolio.

  • November 2020: Stryker acquired Wright Medical to strengthen its biologics portfolio, which includes bone void fillers.


An Infographic Representation of U.S. Bone Void Fillers Market

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The report provides a detailed competitive landscape. It focuses on the market size of different product types. Additionally, it includes the key industry developments, such as partnerships, mergers, and acquisitions. Furthermore, the report covers company profiles of key market players, market growth opportunities, and the impact of COVID-19 on the market. The report also consists of quantitative and qualitative insights that are contributing to the market's growth.

Report Scope & Segmentation



Study Period


Base Year


Estimated Year


Forecast Period


Historical Period


Growth Rate

CAGR of 6.5% from 2023-2030


Value (USD Billion)


By Type

  • Demineralized Bone Matrix

  • Collagen Matrix

  • Calcium Sulfate

  • Tri-calcium Phosphate

  • Others

By Form

  • Gel

  • Granules

  • Paste

  • Putty

  • Others

By Application

  • Spinal Fusion

  • Joint Reconstruction

  • Foot & Ankle

  • Others

By End-user

  • Hospitals and Ambulatory Surgical Centers

  • Specialty Clinics

  • Others

Frequently Asked Questions

Fortune Business Insights says that the U.S. market value stood at USD 1.34 billion in 2022 and is projected to reach USD 2.22 billion by 2030.

The market is expected to exhibit a CAGR of 6.5% during the forecast period of 2023-2030.

By type, the demineralized bone matrix segment is set to lead the market.

The key factors driving the market are the rising prevalence of spinal disorders & bone tumors and the increasing launch of synthetic bone void fillers by the market players.

Zimmer Biomet, Stryker, and Medtronic are the top players in the market.

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