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The global central nervous system treatment market size was USD 81.67 billion in 2020 and is expected to grow from USD 89.02 billion in 2021 to USD 166.53 billion in 2028, at a CAGR of 9.4% in the 2021-2028 period. The global impact of COVID-19 has been unprecedented and staggering, with the central nervous system treatment witnessing a negative demand shock across all regions amid the pandemic. Based on our analysis, the market exhibited a decline of -4.2% in 2020. The sudden increase in CAGR is attributable to this market’s demand and growth returning to pre-pandemic levels once the pandemic is over.
The central nervous system (CNS) treatment market is projected to expand at an incredible growth rate. Over the past years, the world has witnessed a striking increase in neurological disorders' diagnosis rates. According to the Alzheimer's Association, around 6 million people in the U.S. are currently living with Alzheimer, and by 2050, the number of people suffering from the condition is projected to reach 13 million. Also, neurological disorders are exerting a huge economic burden on the healthcare system of various countries. The direct and indirect costs of treatment and management of these conditions is gradually increasing owing to the increasing prevalence. Alzheimer’s and other dementia’s cost around USD 355 billion in direct and indirect costs to the U.S. each year.
Increasing prevalence of neurological disorders, and increasing diagnosis rates in developed and emerging countries is presenting a large patient pool undergoing treatment. This is further supported by the emphasis of non-profit organizations, healthcare systems, and market player towards creating awareness regarding these conditions through campaigns, etc. These factors along with introduction of new generation of antipsychotic drugs by global and domestic players in the market is poised to drive the growth opportunities of the market during the forecast period.
COVID-19 Impact: Damaging Effect on Market Sales
The sudden outbreak of COVID-19 and the virus's consistent spread have significantly obstructed the supply chain of key CNS therapeutics in the market. The pharmaceutical companies that operate in the CNS market have focused their R&D expenditure and workforce towards the development of COVID-19 therapeutics and vaccines. This shift has led to an estimated USD 1.4 billion sales drop in central nervous system treatment in 2020. Additionally, over-the-counter products such as anesthesia and products such as anesthesia have witnessed an increased dip in revenue growth owed to lower demand from respective end-users. However, the market is estimated to stabilize and showcase astounding growth in 2021 attributable to market growth returning to the pre-pandemic level.
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Mergers, Acquisitions, and Partnerships are Key Trends Exhibited by Market
One of the significant trends that the market exhibits are mergers, acquisitions, and partnerships. Predominant companies in the market involved in innovating central nervous system treatment drugs have entered into distribution and developmental agreements with fellow competitors. For instance, in February 2020, Biogen agreed with Sangamo Therapeutics to innovate gene therapy drugs for various neurological diseases. Such strategic steps taken by key companies operating in the CNS therapeutics market will significantly improve the prospects of the industry.
Growing Geriatric Population and Associated Neurological Disorders to Fuel Product Demand
Worldwide, there is a rapid increase in the prevalence and incidence of neurological disorders such as multiple sclerosis, Alzheimer’s, Parkinson’s, among others. According to Public Health England, the number of individuals with multiple sclerosis has increased to over 131,000 in the U.K. for the year 2018. This increase is set to remarkably influence the growth of the market in the coming years.
On the other hand, Alzheimer’s disease is also witnessing an increase in prevalence in countries with a growing geriatric population. For instance, according to the Alzheimer's Association, more than five million individuals are affected by Alzheimer’s disease, and this number is set to rise to 14 million by 2050. Also, the organization reports that the treatment and care for Alzheimer’s cost the U.S. government over USD 305 billion in 2020.
Promising Pipeline Drugs to Create New Growth Prospects
Prospective product launches for treating neurological disorders are anticipated to propel market growth over the forecast duration. These upcoming launches are expected to increase access to treatment in developing countries.
For instance, Lenabasum is currently in Phase 3 clinical trial to evaluate safety and efficacy in the treatment of diffuse cutaneous systemic sclerosis by Corbus Pharmaceuticals Inc. The molecule is set to launch globally by 2023. Also, In January 2019, Corbus Pharmaceuticals Inc. entered into a licensing agreement with Kaken for the commercialization of Lenabasum in Japan. These factors are projected to propel market growth in the coming years.
Time-Consuming Approval Process and Stringent Regulatory Framework to Restrain Market Growth
Central nervous system treatment therapeutic research and development require a higher amount of investment than other therapeutic disease areas. Since the therapeutics developed for central nervous system treatment had to cross the blood-brain barriers, it requires a longer developmental and approval process. The market also faces challenges in patient recruitment and higher cost per approval in the entire pharmaceutical industry.
Moreover, an adverse occurrence with the use of these drugs is also a major factor that is anticipated to hinder the global central nervous system treatment market growth. For instance, in 2018, the U.S. FDA issued a warning notifying that the use of Gilenya in relapsing multiple sclerosis patients could lead to severe disability if the medication is stopped. These issues could restrain the market growth during the forecast period.
Demand for Multiple Sclerosis Drugs to Help Proliferate Market Growth
Based on disease segment type, the global CNS therapeutics market is classified as neurovascular diseases, neurodegenerative diseases, mental health, infectious diseases, and others. Neurodegenerative diseases dominated the market in 2020 owing to the growing sales for multiple sclerosis as well as Alzheimer’s disease drugs due to the rising prevalence of neurological disorders.
Additionally, growing R&D investments with an aim to develop potential drug candidate for the treatment of multiple sclerosis, Alzheimer’s etc. is another factor contributing to the rapid expansion of the market. For instance, in October 2020, Dyno Therapeutics and Roche announced a collaborative license agreement to use Dyno’s CapsidMap platform for the development of next-generation adeno-associated virus (AAV) vectors for gene therapies for CNS disorders and liver-directed therapies for both Roche and Spark Therapeutics, (a member of the Roche Group) product portfolio.
Furthermore, rising cases of mental health disorders among the population owing to increased stress levels, anxiety, and unhealthy diet are also leading to a growing demand for CNS therapeutics. Due to the emergence of COVID-19, mental health disorders have taken a steep climb among the population worldwide, therefore, increasing the sales of antidepressants, analgesics, and others.
Immunomodulators Dominated Market Owed to Higher Sales Revenue
Based on the drug class, the market is divided into immunomodulators, interferons, decarboxylase inhibitors, dopamine agonists, antidepressants, analgesics, and other central nervous treatment drugs. The majority of the share was captured by immunomodulators in 2020. The major factor driving immunomodulators in the market is the constant innovation and development of therapeutic molecules to treat disease indications.
Interferons have followed the lead in terms of market revenue for the year 2020. The increasing incidence and prevalence of neurological disorders are expected to predominantly influence the segments' growth. According to the World Health Organization (WHO) (2019), globally, around 50 million individuals have epilepsy. Besides, antidepressants are estimated to witness considerable growth owing to growing awareness regarding mental health in developing nations.
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Launch of Novel Non-Biologics has Triggered Strong Growth
Based on drug type, the global market has been segmented into biologics and non-biologics. The non-biologics segment dominated the global market in 2020. The dominance is attributable to the lesser imposition of regulations by the regulatory body than that of the biologics for approval.
Additionally, Biogen’s Tecfidera has the highest sales as it is largely prescribed worldwide in the non-biologics segment for treatment against multiple sclerosis. In addition, the rising prevalence of neurological diseases, strong government support, and favorable health reimbursement are key factors driving the growth of the non-biologics segment during the forecast period.
Moreover, factors such as the presence of potential pipeline candidates and government support in the development and approval of the biologic CNS drugs are expected to foster the growth of the biologics segment.
Increasing Sales of Prescription-based Drugs to Support Hospital Pharmacy Segment
Based on the distribution channel, the market is segmented into hospital pharmacies, retail pharmacies, and others. The hospital pharmacy segment captured the lion’s share worldwide attributable to the higher rising preference of treatment from hospitals and more significant sales revenue of prescription drugs from the distribution channel.
The retail pharmacy segment also garners importance in the market because of the increasing access to prescription drugs and discounts offered by retail pharmacy giants. Besides, online pharmacies are projected to witness a lucrative CAGR during the forecast period due to the internet's penetration in emerging countries.
North America Central Nervous System Treatment Market 2020 (USD billion)
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North America dominated the market by generating a revenue of USD 38.25 billion in the year 2020. The dominance of this region in the CNS therapeutics market is attributable to the strong presence of key players in the region combined with higher access to the treatment of CNS disorders. Combined with this, government agencies such as the U.S. FDA are constantly engaging in informing the public and healthcare professionals regarding the treatment and regulatory guidelines for managing CNS diseases.
Europe followed the lead by generating the second largest revenue in the market for the year 2020. This is owed to the favorable reimbursement policies and largest access to treatment through public healthcare providers such as the National Health Service (NHS) of the U.K. Combined with this, the European regulatory approval is also one of the highly recognized approvals by major companies making it one of the most lucrative regions for product launches.
The countries of Asia Pacific are anticipated to showcase stellar CAGR attributed to factors such as the increasing geriatric population, evolving healthcare infrastructure, a larger presence of biosimilar/over-the-counter medication manufacturing countries, and the rising prevalence of neurological disorders.
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On the flip side, Latin America, and the Middle East and Africa are projected to showcase reasonably slower market growth rates due to the lack of product approvals in the region combined with weaker product penetration.
Major Companies Focus on Strong Presence in Emerging Countries Through Partnerships
The market is fragmented due to the presence of various companies aiming at central nervous system therapeutics. Robust pipeline and strategic distribution agreements have enabled companies to hold a strong position in the market.
Biogen dominates the market, with the company’s crucial molecules generating significant revenue in the year 2020. Other players operating in the market are Johnson and Johnson Services, Inc., Pfizer Inc., RF. Hoffman-La Roche Ltd., Novartis AG, Sanofi, Teva Pharmaceutical Industries, Otsuka Holdings, among others.
An Infographic Representation of Central Nervous System Treatment Market
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The global market research report provides a detailed central nervous system treatment market analysis. It focuses on key aspects such as leading companies, drug class type, and distribution channel. Besides this, it offers insights into the market trends and highlights new product launches, key industry developments, and pipeline analysis. In addition to the aforementioned factors, the report encompasses several factors that have contributed to the growth of the developed market in recent years.
Value (USD billion)
Disease Type, Drug Class, Drug Type, Distribution Channel, and Region
By Disease Type
By Drug Class
By Drug Type
By Distribution Channel
Fortune Business Insights says that the global market size was USD 81.67 billion in 2020 and is projected to reach USD 166.53 billion by 2028.
In 2020, the North American market size stood at USD 38.25 billion.
Registering a CAGR of 9.4%, the market will exhibit healthy growth in the forecast period (2021-2028).
The neurodegenerative diseases segment is expected to lead this market during the forecast period.
The increasing prevalence of neurological diseases is the key factor driving the growth of the market.
Biogen, Roche, Johnson and Johnson Services, Inc., and Novartis AG are the global market players.
North America dominated the market in terms of share in 2020.
Asia Pacific region exhibited the highest growth during the forecast period.
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