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The Continuous Renal Replacement Therapy (CRRT) market size was valued at USD 1.01 billion in 2022 and is projected to grow from USD 1.04 billion in 2023 to USD 1.76 billion by 2030, exhibiting a CAGR of 7.8% during 2023-2030.
CRRT plays a vital role in the management of renal function in critically ill patients who suffer from Acute Kidney Injury. It is a slower, continuous, 24-hour dialysis therapy method that helps patients with hemodynamic instability. This therapy involves the removal of solutes from the blood through the process of hemofiltration, hemodialysis, or a combination of both methods. This therapy is a different process as compared to conventional renal replacement therapies as it is carried out continuously in an ICU setting.
In recent years, this procedure has gained significant attention due to the increasing prevalence of Acute Kidney Injury (AKI) and advancements in technology. Other factors attributable to the market growth include a rapidly growing number of ICU admissions across the world, rising incidence of sepsis-related acute kidney injury, and constant new product launches by key industry players.
Increased Usage of CRRT Products in Treating COVID-19 Patients Led to a Positive Market Impact
The outbreak of COVID-19 had a positive impact on the market in 2020 as compared to 2019. This was primarily due to the high number of COVID-19 patients developing acute kidney injury, and thus, requiring ICU admissions.
Furthermore, leading players in this market witnessed a significant revenue growth owing to the high sales of this therapy products during the years 2020 and 2021. For instance, Baxter’s acute therapy segment registered a 38.3% increase in revenue in 2020 compared to 2019 and was valued at USD 740.0 million. Similarly, the segment witnessed a growth of 5.7% in 2021 when compared to 2020.
However, the market witnessed a comparatively lower growth rate in 2021 due to the reduced usage of this therapy with the decreasing number of COVID-19 patients. The market witnessed a negative impact on the growth in 2022 on account of the decline in the demand for CRRT products due to the drop in the number of cases of COVID-19 associated AKI. The market is anticipated to witness steady growth prospects across the forecast period of 2023-2030.
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Surging Preference for Continuous Venovenous Hemodiafiltration (CVVHDF) Modality in this Therapy
In recent years, the market has witnessed several technological advancements, resulting in increasing preference among healthcare professionals for Continuous Venovenous Hemodiafiltration (CVVHDF) as a treatment modality.
Owing to the several advantages offered by Continuous Venovenous Hemodiafiltration (CVVHDF), this modality is increasingly being preferred by in the management of critically ill patients with acute kidney injury. Some of the advantages of this modality include more hemodynamic stability than Intermittent Hemodialysis (IHD), continuous removal of uremic toxins and fluid, and others.
Growing Number of ICU Admissions to Propel Market Growth
The constant increase in the number of patients admitted to intensive/critical care units across the globe is one of the key factors that has driven the continuous renal replacement therapy market growth. Acute kidney injury is one of the common complications occuring in patients admitted in ICUs and is recognized as a major public concern across the globe. The usage of this therapy consistently demonstrates a considerable impact on the management of critically ill patients. This therapy is provided in intensive care unit only for patients having acute kidney injury caused due to several other severe complications such as cancer, diabetes, cardiac surgery, and others. It can be given for 24 hours or a longer duration based on patients’ medical condition.
Furthermore, the growing geriatric population has led to a surge in ICU admissions across the world. The growing geriatric population is anticipated to increase the demand for the treatment and management of acute and chronic health conditions, especially, hypertension, cancer, heart disease, diabetes, and stroke which often require intensive care. Such factors are expected to contribute to the increase in the market size.
Thus, the increasing geriatric population is anticipated to increase the number of ICU admissions which may require this therapy to manage their health conditions.
All the above-mentioned factors are anticipated to propel the market expansion throughout the forecast period.
Rapid Advancements and Launches of New Technologies to Spur Market Growth
Rapid technological advancements and introduction of new innovative products for this therapy has increased its adoption in managing critically ill patients. To meet the continuously evolving demand for CRRT products, the market players are focusing on developing products tailored to specific patient population, such as pediatric patients.
Furthermore, improvements in membrane technology and personalization of continuous renal replacement therapy delivery, along with other extracorporeal therapies are expected to offer additional advantages to patients. Moreover, the usage of data analytics in therapy delivery, automated prescription, and the development of quality metrics also contribute to enhancing the quality of care provided to patients. Such factors are estimated to boost the market size.
Stringent Regulatory Guidelines for CRRT Therapy to Hinder Market Growth
Even though the application of continuous renal replacement therapy for ICU patients holds high potential in managing the burden of acute kidney injury, the presence of stringent regulatory guidelines for product manufacturing and approvals may impede the market growth.
Regulatory authorities across the globally such as the U.S. FDA have imposed strict regulatory requirements for the manufacturing of CRRT products to ensure the availability of high-quality systems in critical/intensive care units for this therapy. Owing to these stringent regulatory guidelines, several products that are already approved in other countries are yet to gain approvals in key countries such as the U.S.
Hence, the presence of stringent regulations, leading to difficulties in access to these systems, is anticipated to slow down the market growth during the forecast period. In addition, higher cost associated with their installation and management compared to other renal replacement therapies is also set to hamper market growth.
Consumables Segment Dominated the Market Owing to Strong Demand for These Products
Based on product type, the market is divided into systems and consumables. The consumables segment is further sub-segmented into dialysates, replacement solutions, filters, catheters, and others.
The consumables segment accounted for the highest market share in 2022 owing to several factors, such as relatively lower prices, repetitive consumption, as well as frequent purchases of these products by patients undergoing AKI treatment. In addition, the COVID-19 pandemic resulted in an increased demand for these products due to the increasing incidence of Acute Kidney Injury (AKI) among COVID-19 patients. Moreover, key players are also focusing on launches of new products as well as obtaining regulatory approvals to fulfill the growing market demands.
On the other hand, the systems segment is anticipated to witness a considerable growth throughout the forecast period. The growth is attributed to higher demand for technologically advanced systems in developed countries compared to the developing countries. In recent years, leading players have focused on the introduction of advanced products to tap into untapped market opportunities.
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Continuous Venovenous Hemodiafiltration (CVVHDF) Segment Dominated Due to Increasing Preference of this Modality
Based on modality, the market is segmented into Slow Continuous Ultra Filtration (SCUF), Continuous Venovenous Hemofiltration (CVVH), Continuous Venovenous Hemodialysis (CVVHD), and Continuous Venovenous Hemodiafiltration (CVVHDF).
Continuous Venovenous Hemodiafiltration (CVVHDF) captured the highest global Continuous Renal Replacement Therapy (CRRT) market share in 2022. The dominance of this segment is majorly attributed to CVVHDF’s ability to completely remove and replace solutes and fluids from the patient’s blood. This therapy is an ideal combination of diffusion and convection to provide clearances over a broad range of solutes. As a result, CVVHDF is the preferred modality in several developed countries.
On the other hand, Continuous Venovenous Hemofiltration (CVVH) was the second-largest revenue generating segment in 2022. Increasing adoption of this modality in developing countries along with the rising number of patients with fluid overload are some of the factors that are supporting the segmental growth. Additionally, Slow Continuous Ultra Filtration (SCUF) and Continuous Venovenous Hemodialysis (CVVHD) are expected to witness reasonable growth throughout the forecast period. Slow Continuous Ultra Filtration (SCUF) is one of the less preferred modes of this procedure by the healthcare professionals prescribing this therapy. Continuous Venovenous Hemodialysis (CVVHD) is considered to be an effective method for the removal of small to medium sized molecules.
On the basis of region, the global market is divided into North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.
North America Continuous Renal Replacement Therapy (CRRT) Market Size, 2022 (USD Billion)
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North America dominated the global market with a share of 39.60% in 2022. Key factors driving the dominance of the region include a high incidence of acute kidney injury among ICU patients, a stronger demand for therapy-related products, and the presence of a well-established healthcare infrastructure. Additionally, increasing support from regulatory bodies and the robust presence of product manufacturers in the region also support the high market share of the region. For instance, in April 2022, Baxter International Inc. received the 510(k) clearance from U.S. Food and Drug Administration for its ST Set used in this therapy. The device can be used with PrisMax or Prismaflex control units.
On the other hand, Europe accounted for the second largest share in the global market. Increasing regulatory approvals in European Union and growing number of cases receiving renal replacement therapy are some of the factors that are driving the European market growth.
The Asia Pacific region is expected to witness the fastest growth during the forecast period. In this region, countries such as Japan and China are expected to demonstrate considerable growth prospects. In Japan, the incidence of AKI accounts for approximately 40% of total ICU admissions and AKI contributes to around 26% of total in-hospital deaths in the country. This high incidence is expected to result in a high demand for renal replacement therapy in the region.
Furthermore, the Latin America and Middle East & Africa regions are expected to witness considerable growth over the forecast period. Factors contributing to this growth include the rising adoption of continuous renal replacement therapy in ICU patients in Latin America region, increasing incidence of acute kidney injury in hospitalized patients, and increasing partnerships between domestic and global players in these regions to offer advanced products.
Baxter to Lead due to Strong Product Offerings and Wider Distribution Network
The competitive scenario of this market reflects a consolidated market structure with leading players such as Baxter, Fresenius Medical Care AG & Co. KGaA (Germany), and B Braun SE accounting for a significant share in 2022. These key players are persistently focusing on expanding their product offerings and entering strategic partnerships with other companies and healthcare providers in order to expand their customer base.
Apart from these players, other prominent players, such as Medtronic, Asahi Kasei Medical Co., Ltd., Infomed SA, and others are also undertaking various strategic initiatives. These initiatives include the introduction of new innovative products and increased investment in R&D expenditure to strengthen their market presence.
An Infographic Representation of Continuous Renal Replacement Therapy (CRRT) Market
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The global market forecast provides an in-depth analysis of the industry. It focuses on key aspects such as leading companies, product type, and modality. Besides this, the report offers insights into market trends, new product launches, key industry developments, technological advancements, and the impact of COVID-19. In addition to the factors mentioned above, the report encompasses several factors that have contributed to the growth of the market in recent years. The report also provides the competitive landscape of the global market.
CAGR of 7.8% from 2023-2030
Value (USD billion)
By Product Type, Modality, and Region
By Product Type
According to Fortune Business Insights, the global market stood at USD 1.01 billion in 2022 and is projected to reach USD 1.76 billion by 2030.
In 2022, the market value stood at USD 0.40 billion.
The market will exhibit steady growth at a CAGR of 7.8% during the forecast period (2023-2030).
By product type, consumables segment led the segment in the market.
Growing number of ICU admissions, rapid advancements and launches of new technologies, and clinical advantage of CRRT over intermittent blood purification are the key drivers of the market.
Baxter, Fresenius Medical Care, and B Braun SE are the major players operating in the market.
North America held a dominating share in the market in 2022.
The surge in the demand for effective treatment of acute kidney diseases, increased adoption of technologically advanced systems, and a considerable patient population base are some of the factors expected to drive the adoption of these products.
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