Epinephrine Market Size, Share & COVID-19 Impact Analysis, By Product Type (Auto-injectors, Pre-filled Syringes, and Ampoules & Vials), By Application (Anaphylaxis, Cardiac Arrest, Respiratory Disorders, and Others), By Distribution Channel (Hospital Pharmacy and Retail & Online Pharmacy), and Regional Forecast, 2023-2030

The global epinephrine market size was valued at USD 1.75 billion in 2022. The market is projected to grow from USD 1.92 billion in 2023 to USD 4.08 billion by 2030, exhibiting a CAGR of 11.3% during the forecast period.

Anaphylaxis is a severe allergic reaction which can be caused due to certain food, insect stings, medications, and allergy immunotherapy injection devices. Epinephrine is used to treat anaphylaxis and asthma attacks. It is administered in various ways, such as intramuscular, subcutaneous, intravenous, and inhalation. The increasing burden of anaphylaxis and asthma has been fueling the demand for epinephrine globally.

For instance, as per data published by the National Center for Biotechnology Information in 2022, asthma affects around 4.0%-6.0% of adults and 10.0% of the children in Germany.

Moreover, favorable reimbursement policies for epinephrine auto injectors, increasing launches of technologically advanced products, and growing prevalence of various diseases, including anaphylaxis, cardiovascular diseases, and others. These factors will support the growth of the global market during the forecast period.

COVID-19 IMPACT

Decline in the Number of Prescriptions during COVID-19 Marginally Impacted the Market

COVID-19 outbreak had a negative impact on the global market in 2020. Factors responsible for the decline in the market included reduced number of patients visit to the doctor’s clinic and supply chain disruption. This resulted in decline in the number of prescriptions in 2020.

For instance, the prescription rate for EpiPen (auto-injector) declined in the U.S. during the COVID-19 pandemic. In 2020, Mylan experienced a decline of 33.7% in total prescriptions filled for its generic EpiPen. Additionally, market players also experienced a decline in the sales of their products during the COVID-19 pandemic in 2020. In 2020, the market players observed a significant decline in revenue. For instance, Amneal Pharmaceuticals LLC recorded a decline of 2.5% in revenues generated in 2020.

However, the market experienced significant growth in 2021. The initiatives taken by governments of various countries for the management of allergic reactions during the COVID-19 pandemic supported the growth of the market in 2021. For instance, in February 2021, the Strategic National Stockpile (SNS) allocated 100,000 auto-injectors to 50 states around the U.S. Moreover, market players also experienced a growth in their revenue in 2021. For instance, in 2021, Amneal Pharmaceuticals LLC registered a growth of 20.1% in revenue compared to the previous year.

LATEST TRENDS

Adoption of AI is Transforming Drug Delivery for Epinephrine

The rising prevalence of medical conditions, such as anaphylaxis, cardiovascular diseases, respiratory diseases (asthma), and others, along with the increasing awareness about treatment options for the management of these diseases, is creating various growth opportunities in the market.

• For instance, according to the Anaphylaxis Campaign report, allergies will affect more than 50% of all Europeans by 2025.


• Moreover, according to the National Center for Biotechnology Information (NCBI) in August 2023, more than 50 million Americans suffer from allergies every year.

Growing advancements in auto-injectors, such as AI-enabled auto-injectors and needle-free auto-injectors, are creating opportunities in the market. The increasing applications of these injectors, apart from anaphylaxis in various medical conditions, such as cardiac arrests, respiratory disorders, and other conditions, are creating more opportunities for the key players to launch the product for various conditions.

Additionally, various key players are adopting growth strategies such as acquisition and collaborations to enhance its offerings in the market that will cater to the unmet needs of the patients.

• In November 2021, Marathon Asset Management acquired kaleo, Inc. to enhance the development and commercialization of the company’s offerings.

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DRIVING FACTORS

Growing Prevalence of Asthma and Huge Patient Pool Undergoing Treatment to Support the Demand for Auto-injectors

With the rising prevalence of anaphylaxis and asthma globally, the demand for these products is increasing in developing and developed countries. For instance, as per the Centers for Disease Control and Prevention (CDC), in 2021, around 24.96 million population in the U.S. suffered from asthma.

To cater to this growing demand, major market players are focusing on the introduction of innovative products offering novel routes of administration. These players are now focusing on developing technologically advanced injectors in the market.

• For instance, in July 2022, ARS Pharmaceuticals and Silverback Therapeutics partnered for regulatory approval and commercialization of Neffy, an epinephrine nasal spray.

Additionally, the market players are focusing on expanding their geographical footprints to cater to the demand for these auto-injectors. In August 2019, ALK-Abelló A/S partnered with Windgap Medical, Inc., a U.S. based pharmaceutical company, to enter the U.S. market with advanced epinephrine auto-injectors.

Adequate Reimbursement Policies in Developed Countries to Drive the Adoption of Auto-injectors    

As the demand for these injections is increasing rapidly in developed countries, such as the U.S. and European countries, companies are focusing on the launch of new products in the market. Moreover, reimbursement policies are improving for these pens as the cost of these auto-injectors is very high and these pens are inaccessible to many patients. For instance, to make these auto-injectors more accessible for patients suffering from anaphylaxis, Medicare offers coverage for the auto-injector through its Part C and Part D drug plans. Part C or the Medicare Advantage (MA) Plan, was established in 2003, whereas the Part D plan came into effect in 2006.

Despite the higher cost of these auto-injectors in developed countries, the penetration is still comparatively higher in these countries. This is due to adequate reimbursement policies available for auto-injectors.

RESTRAINING FACTORS

High Cost of Auto-injectors and Limited Reimbursement in Developing Countries to Limit Market Growth

With increasing demand for effective treatment options for critical reactions to the allergies such as anaphylaxis, the demand for these injections is increasing rapidly. However, the high cost of auto-injectors is projected to limit the global epinephrine market growth during the forecast period.

• For instance, a set of two EpiPen auto-injectors costs around USD 650 to USD 700. Similarly, Auvi-Q injectable 2 kits of 0.1 mg cost around USD 664.4.

In addition, in developing countries, most people are not aware of the treatment options available for anaphylaxis, this factor has been limiting the adoption of the drug in these countries.

Moreover, lack of reimbursement policies in developing countries and higher out-of-pocket expenditure associated with the auto-injectors are responsible for lower adoption of these products in the market.

SEGMENTATION

By Product Type Analysis

Auto-injectors Segment Dominated the Market in 2022 Owing to Various Benefits

By product type, the market is segmented into auto-injectors, pre-filled syringes, and ampoules & vials.

The auto-injectors segment dominated the market in 2022 owing to the benefits of these auto-injectors over other products such as easy usability, convenient handling, and others. Auto-injectors can be used for emergency treatment of acute anaphylaxis as it helps in fast absorption of the drug. Such factors are responsible for the segment growth.

The pre-filled syringes segment is expected to grow significantly during the forecast period. This is due to its quick response to emergency allergic reactions and increasing demand from hospitals and clinics for the treatment of various illnesses.

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By Application Analysis

Increasing Prevalence of Anaphylaxis is Responsible for Dominance of the Segment

On the basis of application, the market is divided into anaphylaxis, cardiac arrest, respiratory disorders, and others.

The anaphylaxis segment dominated the market in 2022, accounting for major global epinephrine market share. The dominance of the segment is attributed to the growing number of cases of anaphylaxis globally. For instance, as per data published by the Centers for Disease Control and Prevention (CDC) in 2021, 25.7% of the adults in the U.S. suffered from seasonal allergy and 6.2% of the adults suffered from food allergy.

The respiratory disorders segment is projected to grow with a significant CAGR during the forecast period. This is due to numerous factors such as rising awareness about the treatment options available for respiratory disorders along with the increasing diagnosis and treatment rate of respiratory disorders.

By Distribution Channel Analysis

Increasing Number of Retail & Online Pharmacy Globally is Responsible for the Segment’s Dominance

On the basis of distribution channel, the market is divided into retail & online pharmacy and hospital pharmacy.

The retail & online pharmacy segment dominated the market in 2022. The factors responsible for the growth of this segment included the increasing number of retail & online pharmacy stores globally, easy presence of auto-injectors, and easy accessibility of the products on the online platforms of the companies.

The hospital pharmacy segment is expected to grow at a substantial CAGR over the forecast period. The increasing emergency hospital visits of the patients due to severe allergic reactions, cardiac arrest, and respiratory conditions, is responsible for the segment’s growth.

REGIONAL INSIGHTS

Based on region, the market has been studied across North America, Europe, Asia Pacific, Latin America, and the Middle East & Africa.

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The market in North America was valued at USD 1.11 billion in 2022. The region dominated the global market. This is due to various factors such as adequate reimbursement policies in the U.S. for auto-injectors and the increasing launch of technologically advanced products in the market. For instance, in May 2020, kaleo, Inc. announced the availability of ALLERJECT auto-injector in Canada. With this availability, Canadian patients were able to access different treatment options for anaphylaxis.

In Europe, the market growth is due to the increasing prevalence of anaphylaxis, cardiovascular diseases, and others. Moreover, the increasing demand for technologically advanced products in the region is also responsible for the regional growth. For instance, according to an article published in the European Journal of Allergy and Clinical Immunology, in March 2020, the prevalence of food allergies in children from birth to 17 years was around 61.6%.

The Asia Pacific is projected to grow at a significant rate over the forecast period. This is owing to changing regulatory policies for the adoption of auto-injectors. Additionally, companies are expanding their global presence in the region to meet the demand. For instance, in July 2021, ALK-Abelló A/S partnered with Grandpharma to launch its adrenaline auto-injector “Jext” in China. Jext is expected to be the first auto-injector in China.

The market in Latin America is growing due to increasing diagnosis and treatment rate of anaphylaxis, which has created a demand for these injections in the region. The launch of new products is supporting the market growth in the region.

The Middle East & Africa market will expand with a considerable market share during the forecast period. This is due to strategic initiatives taken by governments of various countries to control the increasing prevalence of anaphylaxis.

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KEY INDUSTRY PLAYERS

Teva Pharmaceutical Industries Ltd. Leads the Market with Strong Portfolio of Auto-injectors 

The market is consolidated, with a few players holding a major share of the market. Industry leaders, such as Teva Pharmaceutical Industries Ltd., Viatris Inc., and Amneal Pharmaceuticals LLC, are significant players in the market due to the strong sales of their brands, such as EpiPen and EpiPen Jr., among others.

The other market players, such as USWM, LLC., kaleo, Inc., and ALK-Abelló A/S mark a strong global presence. These players have been focusing on partnerships and collaborations to fuel the sale of their products.

• For instance, in August 2022, kaleo, Inc. and Valeo Pharma entered into a ten-year commercialization agreement for ALLERJECT sales in Canada.

LIST OF KEY COMPANIES PROFILED:

• Teva Pharmaceutical Industries Ltd. (Israel)


• Viatris Inc. (U.S.)


• kaleo, Inc. (U.S.)


• Bausch Health Companies Inc. (Canada)


• Amneal Pharmaceuticals LLC. (U.S.)


• USWM, LLC. (U.S.)


• BIOPROJET (France)


• ALK-Abelló A/S (Denmark)

KEY INDUSTRY DEVELOPMENTS:

• March 2023 - Daiichi Sankyo, Inc., through its subsidiary American Regent, Inc., launched sulfite-free Epinephrine Injection, USP, indicated for emergency treatment of type I allergic reaction.


• October 2022 – ARS pharmaceuticals announced that FDA accepted the new drug application for its epinephrine nasal spray, Neffy.


• November 2021 - Marathon Asset Management acquired kaleo, Inc. to accelerate the commercialization, manufacturing, and development of kaleo’s medical products.


• November 2020 - Upjohn, Pfizer Inc.’s division, and Mylan N.V. formed a global pharmaceutical company called Viatris Inc. The company was formed for product development in therapeutic areas such as cardiovascular diseases, central nervous system and anesthesia, and infectious diseases around the world.


• May 2020 - USWM, LLC. and Adamis Pharmaceuticals Corporation entered an agreement to grant commercial rights to USWM, LLC. for the distribution and commercialization of the SYMJEPI injection.

REPORT COVERAGE

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The report provides a detailed market analysis. It focuses on key aspects such as leading companies, product type, applications, and distribution channels. Besides this, it offers insights into the global epinephrine market forecast, market trends, impact of COVID-19, and other key insights. In addition to the factors mentioned above, the report encompasses several factors that have contributed to the growth of the market in recent years.

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