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Prothrombin Complex Concentrate (PCC) Market Size, Share and Global Trend By Product Type (3-factor PCC, 4-factor PCC), By Application (Congenital and Acquired Coagulation Factor deficiency), By End User (Hospitals, Ambulatory Surgical Centers) and Geography Forecast till 2025

Region : Global | Latest Update: Sep, 2019 | Published Date: Apr, 2019 | Report ID: FBI100102| Status : Published



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The Global Prothrombin Complex Concentrate Market was valued at USD 536.3 Million in 2017 and is projected to reach USD 1,076.5 Million by the end of 2025, exhibiting a CAGR of 9.1%.

Prothrombin Complex Concentrate (PCC) holds significant potential in the plasma therapeutics industry in emerging countries. The demand for fresh frozen plasma (FFP), which is considered to be a major alternative therapy to prothrombin complex concentrate, is reducing at a significant rate owing to the longer time it takes for infusion. The increasing focus of key companies towards enhancing the number of plasma collection centers is a key factor contributing to the worldwide prothrombin complex concentrate (PCC) market growth.

Moreover, the proactive governments of key countries are participating in the treatment of rare bleeding disorders by recommending prothrombin complex concentrate usage and stating their dosing guidelines. The rising interest of public authorities in the growing research and regulatory approvals of PCC products is expected to boost the expansion of the global prothrombin complex concentrate (PCC) industry in the forecast period of 2018-2025.

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4-Factor prothrombin complex concentrate (PCC) to Emerge as Most Attractive Product Type 

The annual cost of hospitalization for bleeding associated with warfarin is estimated to be hundreds of millions of dollars, which has become a global challenge. Key players such as CSL Behring are thus focusing on introducing specific therapeutics for warfarin-induced prophylactic bleeding. 4-factor prothrombin complex concentrate (PCC) accounted for a major global prothrombin complex concentrate (PCC) market share in 2017.

Improved penetration of leading 4-factor prothrombin complex concentrate brands such as Kcentra & Beriplex in the emerging countries and the rising number of invasive procedures across the globe are expected to propel the expansion of 4-factor prothrombin complex concentrate (PCC) segment with a remarkable CAGR during 2018-2025. 

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In terms of application, acquired coagulation factor deficiency is likely to be the fastest growing segment for the forecast duration, owing to the proven clinical efficacy of brands such as Kcentra in restoring the reduced clotting factors relatively faster than plasma. Various end users in the global prothrombin complex concentrate (PCC) market are the hospitals, ambulatory surgical centers, and others (physicians’ offices, clinics, emergency centers, long-term & urgent care centers, etc.).

A significant range of funds allocated by the government to the hospital sector of emerging economies is estimated to boost the growth of hospitals by the end of forecast duration.

Improved Supply-demand Balance of Critical Care Therapeutics Enables Market Exhibit Highest CAGR in Asia Pacific

North America generated revenue of US$ 210.2 Mn in 2017 and is anticipated to emerge dominant in the global prothrombin complex concentrate (PCC) market during the forecast period. Growth witnessed in the region is likely to be driven by increasing collaborations between key players & distributors in the U.S., aimed at ensuring the efficient supply of products in the region. Likewise, a high prevalence of congenital coagulation factors deficiency in Europe is projected to augment the growth of the market in the region.

However, the Asia Pacific market is expected to expand at a relatively higher CAGR during 2018-2025, which is attributable to the realigned reimbursement policies for rare blood disorders in the emerging countries of the region, and expansion of plasma collection centers in China and India. 

North America Prothrombin Complex Concentrate (PCC) Market, 2017

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CSL Limited and Shire to Account for More Than Half of the Market Share in Terms of Revenue

CSL Limited emerged as the leading player with the highest market share in 2017, as the company is engaged in realigning its diversification strategy to improve the accessibility of its key brands Kcentra and Beriplex. A significant number of plasma collection centers owned by Octapharma AG and Grifols SA across the globe makes them strategically important players in global prothrombin complex concentrate (PCC) market. Other players operating in the prothrombin complex concentrate (PCC) market are Sanquin, Shire plc, China Biologic Products Limited, Kedrion, etc.

Report Overview

The integration of the plasma industry with rare bleeding diseases has changed the face of bleeding disorders management. Prothrombin complex concentrates (PCC) is one of the widely accepted therapy for the urgent reversal of oral anticoagulants and warfarin. 

The report provides qualitative and quantitative insights on the global PCC market and detailed analysis of market size & growth rate for all possible segments in the market. The market is segmented by product type, applications, and end users. On the basis of product type, the global prothrombin complex concentrate market is categorized into 3-factor PCC and 4-factor PCC. Based on the applications, the market is segmented into congenital coagulation factor deficiency and acquired coagulation factor deficiency. Various end users covered in the report are hospitals, ambulatory surgical centres, and others. Geographically, the market is segmented into five major regions, which are North America, Europe, Asia Pacific, Latin America, and Middle East & Africa. The regions are further categorized into countries. 

Along with this, the report provides elaborative analysis of the global prothrombin complex concentrate (PCC) market dynamics and competitive landscape. Various key insights provided in the report are the prevalence of coagulation factor deficiency, recent industry developments in the global prothrombin complex concentrate (PCC) industry such as mergers & acquisitions, the regulatory scenario in key countries, an analysis in relation to alternative therapies, reimbursement scenario, and key industry trends. 


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By Product Type

  • 3-factor PCC

  • 4-factor PCC

By Application

  • Congenital Coagulation Factor Deficiency

  • Acquired Coagulation Factor deficiency

By End User

  • Hospitals

  • Ambulatory Surgical Centers

  • Others

By Geography

  • North America (USA and Canada)

  • Europe (UK, Germany, France, Italy, Spain, Scandinavia and Rest of Europe)

  • Asia Pacific (Japan, China, India, Australia, Southeast Asia and Rest of Asia Pacific)

  • Latin America (Brazil, Mexico and Rest of Latin America)

  • Middle East & Africa (South Africa, GCC and Rest of Middle East & Africa)

Key companies covered in the report

  • Grifols SA

  • CSL Behring

  • Octapharma AG

  • Sanquin

  • Shire

  • Kedrion S.p.A

  • China Biologic Products Holdings, Inc.

  • Other players

Prothrombin Complex Concentrate PCC Market Size, Share and Global Industry Trend Forecast till 2026
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