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Plasma Fractionation Market Size, Share & COVID-19 Impact Analysis, By Product (Albumin, Immunoglobulin (Intravenous Immunoglobulin (IVIG), Subcutaneous Immunoglobulin (SCIG)), Coagulation Factors (Factor IX, Factor VIII, Prothrombin Complex Concentrates, Fibrinogen Concentrates, andOthers), Protease Inhibitors and Others), By Application (Immunology & Neurology, Hematology, Critical Care, Pulmonology, and Others), By End-user (Hospitals & Clinics, Clinical Research Laboratories, and Others), and Regional Forecast, 2023-2030

Region : Global | Format: PDF | Report ID: FBI101614



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The plasma fractionation market size was valued at USD 30.64 billion in 2022 and is projected to grow from USD 32.75 billion in 2023 to USD 53.33 billion by 2030, exhibiting a CAGR of 7.2% during 2023-2030. North America dominated the global market with a share of 56.00% in 2022.

Plasma fractionation has always ignited curiosity among researchers and industrialists alike. The therapeutic efficacies of blood plasma to treat and manage immunodeficiency diseases have helped the growth of the market. Cryo precipitation and ethanol fractionation are the major processes to separate therapeutic protein components from whole blood in the plasma fractionation equipment. Protein components, such as prothrombin complex, thrombin, fibrinogen, and others, play a major role in managing diseases. These fractionation plasma products have therapeutic efficiencies in treating diseases such as congenital metabolic deficiencies, trauma, immunological disorders, and other life-threatening diseases.

In response to the high demand for plasma derived products, major companies in the market have engaged in several R&D initiatives to launch new plasma-derived therapies.. Furthermore, these key market players also intensely focused on owning and acquiring new plasma collection centers to streamline the availability of plasma to develop new products.

For example, in December 2021, Grifols, S.A., through its Subsidiary company Grifols Canada Therapeutics Inc., acquired all the shares of Prometic Plasma Resources Inc. Similarly, in April 2021, CSL Plasma and Terumo Blood and Cell Technologies announced a collaboration to develop and deliver a new plasma collection platform at the U.S. CSL Plasma Collection Centers. Therefore, the major companies' strategic efforts are expected to drive the global plasma fractionation market growth.


Disruption in Plasma Collection due to Stringent COVID-19 Guidelines Impacted the Global Market

The COVID-19 outbreak led to various organizations experimenting with plasma-based therapies for the treatment of infected individuals. Several companies launched various research & development initiatives to combat COVID-19. For instance, in 2020, Biotest AG entered into industry-wide cooperation within the COVID-19 Plasma Alliance along with companies such as LFB, CSL Behring, Takeda Pharmaceutical Company Limited, and Octapharma AG. The companies together worked on a new polyclonal hyperimmunoglobulin drug against SARS-CoV-2. 

However, the market experienced slow growth due to the disruption in the plasma collection process. Despite being called an “essential infrastructure,” plasma collection was impacted due to the growth in the number of cases and COVID-19 guidelines such as social distancing and stay-at-home orders. For example, according to the annual report published by CSL Limited for the year 2020/2021, due to COVID-19, the plasma collection volume decreased, along with an increase in the cost of the collection with respect to donor compensation. Furthermore, the revenues for major companies were also impacted.

The market is witnessing normalcy in the post-pandemic due to the upliftment of the stringent regulations that were implemented during the pandemic. The companies have witnessed a significant increase in their plasma collection volume and revenue in the post-pandemic years.

  • For instance, in 2022, Grifols, biopharma business observed an increase of 25% volume growth in the plasma collection.

  • Additionally, CSL witnessed a growth of 10.0% in its revenue in the year 2021 as compared to the previous year.


Launch of New Technologies by Key Players to Augment Market Growth

This process involves breaking down plasma into various individual proteins, such as albumin, immunoglobulin and coagulation factor, and protease inhibitor, for clinical use. Major key players in this market have their  plasma fractionation centers where they can extract such proteins. The current demand for plasma-derived therapies led to the launch of various technologies which can make the process faster. For instance, in April 2021, GEA delivered a new separator technology to Biopharma S.A. in its new plant in Bila Tserkva, Ukraine.

In March 2022, the U.S. Food and Drug Administration also cleared Terumo Corporation’s BCT collection system to meet the increasing demand for plasma-derived therapies. Rika Plasma Donation System is said to be a next-generation automated technology designed to meet the growing demand for plasma-derived therapies. On average, the device can complete plasma collection within 35 minutes, ensuring that at one time, there are not more than 200 milliliters of blood outside the donor’s body. The continuous efforts by various players to introduce technologies for the plasma fractionation process will augment the growth opportunities for the market over the forecast period.

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Growing Incidences of Immunodeficiency Disorders Propel the Growth of the Market

There has been a considerable surge in demand for plasma-derived therapies across the world. The demand for immunoglobulin increased strongly, leading to positive growth in the global market. The growing demand is due to the rise in cases of various immunodeficiency disorders worldwide.

Primary immunodeficiency is a group of 300 diseases characterized by recurrent chronic infections, autoimmunity, allergy, or inflammation. These infections are a consequence of genetic alteration, which affects the immune system. The treatment for such disorders can be done through immunoglobulin substitution or specific immunoglobulin therapies. Therefore, the growing requirement for such treatments leads to increased immunoglobulin production by these processes, thus driving the market. For instance, according to UNAIDS, in 2020, there were 37.7 million people globally suffering from Human Immunodeficiency Virus (HIV). The U.S. Food and Drug Administration (FDA) has approved IVIG for children with HIV to reduce the risk of bacterial infections. Therefore, the growing incidences of these immunodeficiency disorders, along with various other diseases, led to the increasing demand for plasma-derived therapies, thus boosting the growth of the global market.

Surge in Demand for Plasma Derived Medicinal Products Drives the Market Growth

Plasma-Derived Medicinal Products (PDMPs) are prepared industrially with the help of human plasma. These products include albumin, immunoglobulins, and coagulation factors. The World Health Organization (WHO) included several PDMP products in the model list of essential medicines. This initiative highlighted these medications to be effective and safe for major needs in a health system. The strong requirement for plasma-derived products increases the demand for these procedures, leading to positive market growth. For instance, primary immunodeficiency diseases can be treated with immunoglobulin by replacing the missing IgG serotype antibodies. However, Von Willebrand (VWD) Disease and hemophilia require the replacement of coagulation factors. Plasma therapies also play an important role in prenatal and intensive care and thus are proven essential for serious deficiencies.

According to an article published by the National Center of Biotechnology Information (NCBI) in 2019, a worldwide shortage of IVIG and the COVID-19 pandemic also added to the ongoing shortage of plasma supply. During the same period, the demand for plasma-derived therapies also witnessed a surge as they proved to be a potential treatment for the new disease. With the surge in demand, major companies started various R&D initiatives to introduce products in the market and cater to global demand.

For instance, the U.S. Food and Drug Administration (FDA) has approved the Investigational New Drug (IND) application submitted by Octapharma AG for a phase three clinical trial on the efficacy and safety of Octagam 10% [Immune Globulin Intravenous (Human)] therapy in COVID-19 patients with severe disease progression. The rising adoption of PDMPs for rare immunodeficiency diseases and various other neurological and hematological disorders leads to an increase in the production of plasma-derived products, thus eventually contributing positively to market growth.


Emergence of Recombinant Therapies as an Alternative to Plasma-Derived Medicines Restraints the Market Growth

In recent years, many recombinant alternatives have been developed for various plasma-driven therapies. Recombinant products are used prophylactically and are comparatively less immunogenic than plasma-derived products. In addition, various other longer-acting replacement factors are in the development pipeline. The products provide significant benefits, such as  less frequent administration, and are more effective in prophylactic use. The growing use of recombinant factors and their increased use in prophylactic therapies is thus a major factor limiting the adoption of plasma products.

The recombinant product version of plasma-derived products is manufactured by the expression of equivalent proteins from genetically engineered cells and offers a safer option than plasma-derived products as they avoid potential blood-borne transmission of infectious diseases. Therefore, the advantages associated with such products make them more reliable than plasma-derived products, thus restraining market growth.


By Product Analysis

Immunoglobulin Segment Dominates the Market Due to High Product Demand for Key Diseases 

Based on product, the market is categorized into albumin, immunoglobulin, coagulation factors, protease inhibitors, and others. The immunoglobulin segment can be sub-segmented into Intravenous Immunoglobulin (IVIG) and Subcutaneous Immunoglobulin (SCIG). The coagulation factors segment can be further sub-segmented into factor IX, factor VIII, prothrombin complex concentrates, fibrinogen concentrates, and others.

The immunoglobulin segment dominates the market, contributing to a higher market share. The dominance is attributable to the high demand for IVIG products for primary and secondary immunodeficiency diseases. Growing prevalence and improvement in treating such diseases have led to a surge in demand for intravenous immunoglobulin. Significant product launches by major market players also boost the growth of the segment dominated by coagulation factors.

The growth of the segment of coagulation factors, also known as coagulation factor concentrates, in 2022 is due to the development of hemostasis technology has led to the introduction of a wide range of products that can help clinicians provide adequate assistance to hemophilic patients. Growing accidents and trauma cases also drive the segment's growth. According to the PubMed Central published article, the mortality rate in some severely injured trauma patients is 3 to 4 times higher than those without coagulation complications. The growth in using albumin in various applications, such as cardiovascular diseases, sepsis, and cirrhosis, led to the segment's growth in 2022. For instance, according to an article published by BioSupply Trends Quarterly in 2019, albumin is used as a leading treatment for advanced liver disease in China. It is estimated that 28 million patients require treatment, along with 7 million people who require urgent, intensive treatment for advanced liver disease. Furthermore, almost 2.5 million people live with cirrhosis or liver cancer requiring urgent treatment, sometimes including albumin administration.

The protease inhibitor segment is expected to grow at a comparatively higher CAGR than other segments as protease Inhibitors have wide applications in the diagnosis and treatment of various bacterial, viral, and parasitic diseases. Furthermore, protease inhibitor-based drugs are increasingly used for treating immunological disorders, cancers, and cardiovascular and neurodegenerative disorders. The rising burden of various infectious and chronic disorders is anticipated to increase their demand. Additionally, manufacturers are shifting their focus to research and launch new protease inhibitor-based drugs. Thus, these factors are contributing to the growth of the segment.

  • For instance, in May 2023, Pfizer Inc. received the U.S. FDA clearance for its drug PAXLOVID, a 3CI protease inhibitor-based oral tablet for the treatment of adults suffering from mild to moderate COVID-19 with a risk for progression to severe infection.

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By Application Analysis

Adoption of Plasma Proteins in Immunology & Neurology Procedures Drives the Segment Growth

Based on application, the global market is segmented into hematology, critical care, pulmonology, immunology & neurology, and others.

The immunology & neurology segment is projected to grow at a higher growth rate during the forecast period and had a comparatively higher market share in 2022. The increasing burden of immunodeficiency and autoimmune diseases led to strong global demand for these products. The growing prevalence of immunological & neurological diseases led to the extensive use of plasma proteins such as coagulation factors and immunoglobulins in various treatment procedures. Combined with this, numerous plasma-based proteins are under development or undergoing clinical trials for neurology and immunology applications, leading to the segment's growth in the forecast period.

The pulmonology segment is anticipated to grow at the moderate CAGR during the forecast period. The development of the segment can be due to the use of IVIG in various pulmonary diseases. For example, as per an article published in ScienceDirect in 2019, intravenous immunoglobulin treatment has been proven as a salvage therapy for patients with active and progressive Interstitial Lung Disease who do not respond to the combination of steroids and first-line immunosuppressant drugs.

The hematology segment held a substantial market share in 2022 due to advancements in several hemostasis technologies, leading to its global adoption and growth of the hematology segment. Furthermore, the prevalence of congenital bleeding disorders positively drives market growth. The growing number of trauma cases and accidents across the globe led to the surge in demand for plasma-derived products such as coagulation factors in the critical care segment, thus driving the growth in the segment’s revenue.

By End-user Analysis

Strong Demand for Plasma Products in Hospitals & Clinics Enable Them to Be in  a Leading Position

In terms of end-user, the market is categorized into hospitals & clinics, clinical research laboratories, and others (academic institutes). The hospitals & clinics segment is projected to generate the highest revenue in the global market during the forecast period. The segment's growth is attributed to the increasing number of people opting for plasma-derived therapies across the globe. Various private hospitals with improved infrastructure and technology have adopted plasma-derived therapies and are prescribing their patients suffering from rare immunodeficiency diseases. For example, the Brazilian Rare Disease Network (BRDN) is under development, comprising 40 institutions, including 18 university hospitals, 17 Rare Diseases Reference Services, and five Newborn Screening Reference Services.

The clinical research laboratories segment is expected to grow at the highest CAGR during the forecast period. The growth is due to the increasing demand for plasma therapy in rare diseases and growing R&D initiatives to develop more PDMP products for clinical applications.

The other segment constitutes organizations such as academic institutes and is expected to grow at a significant CAGR in the forecast period. Currently, plasma samples are being preferred more over serum samples as they contain higher concentration of blood components, and thus are often used in proteomic and metabolic studies. Moreover, plasma retain clotting factors unlike serum because of which it becomes an ideal sample for analyzing blood clotting diseases and develop anticoagulant therapies. Thus, the factors mentioned above is augmenting the segment’s growth.


North America Plasma Fractionation Market Size, 2022 (USD Billion)

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North America stood at USD 17.16 billion in 2022 and is estimated to dominate the global market during the forecast period. The highest plasma fractionation market share of this region is attributed to several factors. Some factors include the presence of major companies developing & launching technologically advanced plasma-derived therapies and products, contributing positively to the region’s growth. Furthermore, the presence of a maximum number of plasma fractionation centers in the U.S. significantly contributes to market growth.

Europe, on the other hand, secured the second position in terms of market share and will continue with its position in the upcoming years. This is due to the rising prevalence of immunodeficiency and bleeding disorders in the region, and increasing investments that is augmenting the market growth in the region. For example, according to a 2021 article published by the NCBI, Common Variable Immunodeficiency (CVID) affects approximately 1 of 25,000 individuals, with a higher prevalence in northern Europe.

Increased expenditure on pharmaceutical products and evolving healthcare research infrastructure in India and China led to increasing demand for plasma-derived products, thus driving market Asia Pacific plasma fractionation market growth. Furthermore, the growing prevalence of hemophilia in Asian countries is expected to positively affect the market growth in Asia Pacific. For instance, according to a press release published by Grifols in 2020, the per capita consumption of albumin in China is 325 grams per 1,000 population and ranks 8th globally.

Latin America and the Middle East & Africa are estimated to register comparatively slower growth during the forecast period. However, the prevalence of autoimmune diseases in the regions contributes positively to market growth. For example, as per a study published by the National Library of Medicine in 2019, the prevalence of autoimmune diseases in regions of Brazil was 673.6 cases per 100,000 inhabitants, with the highest prevalence for Hashimoto’s thyroiditis at 140.6 cases per 100,000, followed by Vitiligo 132.4 cases per 100,000, and rheumatoid arthritis 105.9 cases per 100,000. Furthermore, there have been continuous government initiatives for improving healthcare infrastructure and facilities by focusing on a strategic partnership to fulfill the unmet needs of plasma-derived medicines in patients suffering from immunodeficiency disease and autoimmune disorders. For instance, in November 2020, Grifols and the National Service Projects Organization (NSPO) entered into a strategic alliance to develop the local plasma-derived therapies market by opening 20 plasma centers and constructing production facilities in Egypt, including a plasma fractionation plant and a protein purification plant.


Significant Efforts by CSL and Grifols, S.A. to Launch New Products to Strengthen its Global Market Position 

In terms of competitive landscape, companies such as CSL and Grifols, S.A., hold the major shares of the market. Higher expenditure for R&D initiatives and increased focus on opening new plasma collection centers in various countries have increased their dominance in the global market. For instance, in March 2021, Biomat USA, Inc., a subsidiary of Grifols, S.A. acquired 7 plasma donation centers in the U.S. from Kedplasma, LLC. Another factor contributing to the company's dominance is the approvals from regulatory authorities to launch new plasma products for the treatment of chronic diseases. For instance, in April 2023, Takeda Pharmaceutical Company Limited received FDA approval for the expanded use of HYQVIA (immunoglobulin infusion) to treat primary immunodeficiency disorder in children.

Other major players in the global plasma fractionation industry are Baxter, Kedrion S.p.A, and Takeda Pharmaceutical Company Limited, among others. Continuous efforts in launching advanced products and investments in RD are attributable to the increased market presence of these companies in the global market. In June 2021, Kedrion Biopharma and Kamada Ltd. announced that they received approval from the U.S. FDA to update the label for KEDRAB (Rabies Immune Globulin [Human]). The updates are based on KEDRAB U.S. post-marketing pediatric study.



  • March 2023 – Grifols, S.A. established a manufacturing facility in Marburg, Germany, with an expanded manufacturing capacity for human plasma therapies.

  • March 2023 – Takeda Pharmaceutical Company Limited invested USD 764.6 million to build a new plasma-derived therapy production site in Osaka, Japan. The facility will be operational by 2030 and will expand the company’s manufacturing capacity by fivefold in Japan.

  • January 2022 – Octapharma AG announced that the European Union (EU) expanded the indication for cutaquig, a human immunoglobulin administered subcutaneously. The expansion would provide more flexible treatment options to patients with acquired immune deficiencies.

  • January 2022 – Permira announced a partnership with the Marucci family and FSI, the existing shareholders of Kedrion S.p.A., to jointly acquire and combine Kedrion and Bio Products Laboratory (BPL). The two companies' partnership would create a global player for medicines derived from human plasma to treat life-threatening and rare conditions.

  • January 2022- Kedrion S.p.A. and LFB formed an industrial cooperation agreement to increase the availability of immunoglobulins for patients in France. Following the agreement, immunoglobulins manufactured by Kedrion S.p.A will be imported by LFB in France and distributed among hospitals in this region along with their immunoglobulins.

  • January 2022- Bio Products Laboratory Ltd. announced that the National Medical Products Administration (NMPA) for China granted the company a license to market ALBUMINEX 25% in China.


An Infographic Representation of Plasma Fractionation Market

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The global market report provides detailed market analysis and focuses on key aspects such as the overview of the types of plasma fractionation products, regulatory scenario by key countries, reimbursement scenario by key countries, pipeline analysis, number of plasma collection centers for key countries, prevalence of chronic diseases by key countries, pricing analysis of plasma products, regional distribution of plasma fractionation throughput, and distribution of the product (volume) by region. Additionally, it includes an overview of new product launches/approvals, global market forecast, and the impact of COVID-19 on the global market. Besides these, the report offers insights into market trends and highlights key strategies by market players. In addition to the aforementioned factors, the report encompasses several factors that have contributed to the growth of the market in recent years.

Report Scope & Segmentation



Study Period


Base Year


Estimated Year


Forecast Period


Historical Period


Growth Rate

CAGR of 7.2% from 2023-2030


Value (USD Billion)


By Product

  • Albumin

  • Immunoglobulin

    • Intravenous Immunoglobulin

    • Subcutaneous Immunoglobulin

  • Coagulation Factors

    • Factor IX

    • Factor VIII

    • Prothrombin Complex Concentrates

    • Fibrinogen Concentrates

    • Others

  • Protease Inhibitors

  • Others

By Application

  • Immunology & Neurology

  • Hematology

  • Critical Care

  • Pulmonology

  • Others

By End-user

  • Hospitals & Clinics

  • Clinical Research Laboratories

  • Others


By Geography

  • North America (By Product, By Application, By End-user, and by Country)

    • U.S. (By Product)

    • Canada (By Product)

  • Europe (By Product, By Application, By End-user, and by Country/Sub-Region)

    • U.K. (By Product)

    • Germany (By Product)

    • France (By Product)

    • Italy (By Product)

    • Spain (By Product)

    • Rest of Europe (By Product)

  • Asia Pacific (By Product, By Application, By End-user, and by Country/Sub-Region)China (By Product)

    • Japan (By Product)

    • India (By Product)

    • Australia (By Product)

    • Southeast Asia (By Product)

    • Rest of Asia Pacific (By Product)

  • Latin America (By Product, By Application, By End-user, and by Country/Sub-Region)

    • Brazil (By Product)

    • Mexico (By Product)

    • Rest of Latin America (By Product)

  • Middle East & Africa (By Product Type, By Application, By End-user, and by Country/Sub-Region)

    • GCC (By Product)

    • South Africa (By Product)

    • Rest of Middle East & Africa (By Product)

Frequently Asked Questions

Fortune Business Insights says that the global market size was USD 30.64 billion in 2022 and is projected to reach USD 53.33 billion by 2030.

In 2022, North America stood at USD 17.16 billion.

Registering a CAGR of 7.2%, the market will exhibit steady growth during the forecast period (2023-2030).

The immunoglobulin segment is expected to be the leading segment in this market during the forecast period.

Growing incidences of immunodeficiency disorders propel the growth of the market.

CSL and Grifols, S.A. are the major players in the global market.

North America dominated the market share in 2022.

The introduction of advanced therapies by market players is expected to drive product adoption in the global market.

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