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The global transplantation market size was valued at USD 12.11 billion in 2021. The market is projected to grow from USD 14.37 billion in 2022 to USD 27.18 billion by 2029, exhibiting a CAGR of 9.5% during the forecast period. The global COVID-19 pandemic has been unprecedented and staggering, with transplantation experiencing lower-than-anticipated demand across all regions compared to pre-pandemic levels. Based on our analysis, the global transplantation market exhibited a decline of 52.5% in 2020 as compared to 2019.
Transplantation is a surgical procedure of taking an organ or living tissue and implanting it in another part of the body or another body. The rising demand for these procedures and the launches of novel products to prevent the failure of these procedures is one of the foremost factors contributing to the market growth. Organ failure cases usually occur due to various factors, including severe trauma, blood loss, poisoning, drug abuse, leukemia, sepsis, and other acute diseases. This has led to a vast global demand for tissue and organ transplantation, which includes organs such as kidneys, liver, heart, and lungs. For instance, an article published by Economic Times in March 2022 estimated that 220,000 patients require kidney transplantations annually in India. However, only 7,500 of these procedures are carried out. Such strong demand for these transplant procedures in key countries is anticipated to drive the market growth in the transplantation market forecast period.
Additionally, various non-government and government groups are helping to disseminate awareness regarding the importance of organ donation. For instance, in the U.K., the government agency National Health Service (NHS) carries out regular public awareness drives to educate and encourage individuals to register for organ donations. Such programs are expected to surge the market growth.
How does COVID-19 Exert a Strong Negative Influence on the Global Market?
The COVID-19 outbreak affected the global market due to a decline in the number of injuries and trauma incidents across the globe. Another factor that deepened the negative impact of the COVID-19 pandemic in 2020 was the decrease in the number of patient visits to healthcare professionals owing to the coronavirus. For instance, as per data recorded by the United States Department of Health and Human Services (HHS), in 2021, the COVID-19 pandemic has significantly impacted the number of organ transplant procedures in the U.S., with 39,036 procedures performed in the U.S. in 2020 as compared to 39,719 in 2019, representing a decline of 1.7%. Thus, a number of procedures were adversely impacted by the reduction in patient visits.
Furthermore, the pandemic has negatively impacted the sales of products across the globe. Prominent companies in the market reported substantial sales declines in their annual revenues for FY 2020. For instance, key companies in the global market, such as the product segment of Astellas Pharma Inc., and the S.E.T segment of Zimmer Biomet, recorded substantial declines in sales performance. Additionally, the company, BioLife Solutions, which has a strong presence in the global market in terms of its preservation solutions portfolio, witnessed an increase in its revenues in 2021 compared to 2020. For instance, the ‘Cell Processing' segment witnessed an increase of 45.3% in 2021 compared to FY 2020. However, greater adoption of technologically advanced offerings coupled with increased patient visits is expected to raise the market and return to its pre-pandemic growth rate. For instance, an article issued by Organ Donation and Transplantation Meeting 2030 in July 2021 states that the last decade has seen substantial progress in organ donations in the U.K., during which deceased organ donation rates have increased by 56.0%. Thus there has been an exponential rise in the number of transplantation procedures in the U.K.
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How do Collaborations between Public and Private Players and FDA Approvals for New Indications Contribute to the Market Growth Prospects?
The market has witnessed numerous strategic collaborations over the years. The rising cases of organ failures have led to an extreme necessity for transplantation. Therefore, many key players are continuously focusing on building their product portfolio and are also focused on increasing the number of transplantation procedures through collaborations. For instance, the Transplant Therapeutics Consortium (TTC) has collaborated with the transplant community, including stakeholders such as industry, academia, professional societies, and regulatory agencies. The TTC is managed and supported by the Critical Path Institute (C-Path). It is co-founded by the American Society of Transplantation (AST) and the American Society of Transplant Surgeons (ASTS).
Further, the Sectoral Coordination of Transplants, Seville-Huelva, Spain, signed a public-private collaboration agreement with several hospitals in Seville, Spain in 2012. The agreement aims to support the process of organ and tissue donation in the Intensive Care Unit (ICU) setting without transferring to the potential donor, thus guaranteeing that the donor can participate in this process. Also, it added to a training program for the ICU and OR staff of the private sector. Such market drifts is expected to sturdily contribute to the market's growth in the estimated period.
How Rise in Demand for Transplantation Procedures is Driving Market Development?
A substantial rise in the number of transplantation procedures worldwide is a major factor likely to push the overall market growth. The rising prevalence of chronic diseases such as cancer, kidney failure, COPD, and lupus frequently leads to extensive tissue and organ damage. The upsurge in organ failures is among the most crucial growth factors for the global market. For instance, according to preliminary data from the Organ Procurement and Transplantation Network (OPTN), in 2021, 41,354 organ transplants were performed in the U.S. There was an increase of 5.9% over 2020, and for the first time, the annual total exceeded 40,000.
Furthermore, emerging and developed nations, including the U.S. and the U.K., are continuously putting efforts to raise awareness amongst the population regarding organ donation. The emphasis on developed healthcare infrastructure and implementing favorable reimbursement policies are propelling the market's growth. For instance, the National Organ and Tissue Transplant Organization (NOTTO) is a national-level organization set up under the Directorate General of Health Services, Ministry of Health, and Family Welfare. It conducts coordination and networking activities for the procurement and distribution of Organs and Tissues Donation and Transplantation registry in India.
How Technological Advancements in Tissue Products Augment the Growth Prospects?
One of the distinguishing factors expected to push market growth is the development of technologically advanced tissue products. Some emerging technologies in tissue products include autologous stem cell transplant, which has become convenient due to the advent of induced Pluripotent Stem Cells (iPSC). Scientists are trying to develop organs from human-induced pluripotent stem cells.
Furthermore, novel technologies, such as three-dimensional (3D) bioprinting, decellularization and recellularization, and interspecies organogenesis, are being utilized to overcome immunologic hurdles. Prominent players are focusing on launching novel tissue products in the market. For instance, in August 2021, AlloSource launched the AlloMend Ultra-Thick Acellular Dermal Matrix (ADM) to create innovative cellular and tissue products to help surgeons heal their patients. Therefore, integrating such unique tools will decisively boost market expansion.
How Extensive Wait Time for These Procedures in Various Countries is Hindering Growth Prospects?
There is an increased need for these procedures to care for the critically patient population effectively; still, one of the substantial hindrances to market growth is the extensive wait times for transplantation procedures, especially in emerging countries. For instance, as per the statistics published by Health Systems Bureau (HSB) (2021), there are a total of 90,483 kidney patients and 11,891 liver patients on the waiting list in the U.S. However, fewer organ donations eventually increase the waiting time for these procedures. According to an article published by BMC in 2020, as per the study the average waiting time for kidney transplant was 386.22 days in Iran. The unmet demand for transplant procedures is anticipated to augment the market growth.
Additionally, in developing countries, most people are unaware of the options for these procedures, and there is an abundance of inadequate reimbursement policies. According to an article published by Kidney 360 in December 2021, the median waiting time for a deceased donor kidney transplant is three years in Brazil. All the above mentioned factors could impede the market growth.
Significant Product Launches to Enable Tissue Products Held Largest Transplantation Market Share in 2021
The global market can be segmented based on product type into tissue products, immunosuppressive drugs, and preservation solutions. The tissue products segment held a dominant market share due to increased R&D initiatives by various medical devices companies leading to product launches. Also, the rising trauma and injury cases significantly propel the segment’s expansion. For instance, in June 2022, Arthrex Inc. funded and granted support to a soft tissue injury research project. The project was conducted in collaboration between the Orthopedic Research and Education Foundation (OREF) and Orthopedic Trauma Association (OTA).
The immunosuppressive drugs segment is expected to witness positive growth prospects and is the second largest segment. This is due to the benefits these drugs offer, lowering the body's ability to reject a transplanted organ. The preservation solutions segment is expected to grow significantly during the forecast period due to increasing technological advancements in these products, making them more cost-effective and having several logistical advantages and features.
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Escalating Injury Cases Favor the Tissue Segment’s Dominance in 2021
In terms of application, the market is divided into organ transplantation and tissue transplantation. The tissue transplantation segment has captured higher market share in terms of revenue generation as replacing skin, cornea, bones, heart valves, tendons, nerves, and veins is among the most commonly performed procedures worldwide. The escalating number of burn and accident cases is also expected to propel the demand for these procedures. According to an article published by the American Burn Association in 2020, approximately 450,000 individuals in the U.S. suffer from severe burns that require medical intervention. Such statistics contribute to the segment’s growth.
The organ segment is estimated to grip the significant position in the marketplace due to the rising number of transplant procedures due to the increased prevalence of various chronic diseases such as cancer, kidney failure, Chronic Obstructive Pulmonary Disease (COPD), and lupus. For instance, according to the National Institutes of Health (NIH), in September 2021, approximately 786,000 patients in the U.S. are suffering from End-stage Kidney Disease (ESKD); out of that, 71.0% are on dialysis and 29.0% are living with a kidney transplant.
Strong Procedural Volume in Hospitals to Boost Segment’s Growth from 2022-2029
On the basis of end-user, the market is fragmented into hospitals, transplantation centers, and others. The hospitals segment dominates the market and is likely to grow as hospitals are primary care centers for treatment and these procedures. Furthermore, favorable health reimbursements for these procedures and a rise in the number of equipped hospitals are vital prospects for contributing to the hospital's segment.
The transplantation centers is expected to hold prominent position in 2021. The rise in the number of these specialized institutions in developed and developing regions is anticipated to contribute to this segment. According to Donor Alliance Inc., there are more than 250 Transplant Centers in the U.S. The others segment is expected to witness limited growth prospects due to the lesser number of these procedures conducted in these institutions.
North America Transplantation Market Size, 2021 (USD Billion)
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On the basis of region, the global market is fragmented into Europe, Asia Pacific, Latin America, the Middle East & Africa, and North America.
The North America market size was valued at USD 5.08 billion in 2021, and the region is estimated to dominate the global market. The market will be expected to maintain its leadership due to the substantial demand for novel tissue transplantation products and organ transplantation. Other factors that bolstered the development of the market are satisfactory reimbursement plans and the fast adoption of three-dimensional (3D) bioprinting across the region. Furthermore, the presence of prominent companies in the U.S. and the regulatory approvals for innovative items are some common contributing factors to the significant growth of the North America market.
The European market is expected to be the second-largest market in 2021. The growth can be attributed to the increase in these procedures and the vital initiatives by various governments to raise awareness about organ donations in the region. As per an article published by the Nature Reviews Nephrology in 2021, a group of prominent European stakeholders is collaborating within a Thematic Network, presented with an outline of challenges to increase the rates of these procedures. It has proposed 12 critical areas along with specific measures that should be considered to promote the conduction of these procedures.
The market in Asia Pacific is projected to grow significantly in 2021. In Asia Pacific, cases of organ failures are observed to be considerably high due to the rising existence of chronic diseases among the geriatric population.
Latin America is also expected to gain momentum during the forecast period. A large number of organ donation registrations in Mexico and Brazil could provide lucrative opportunities for leading market players. According to an article published by Rev Bras Enferm in 2021, in 2019, total 11,399 potential donors were registered, growing by 6.0% over the year before, and 3,768 effective donors increased by 7% in Brazil.
The Middle East and Africa are expected to witness decent growth in the projected period due to the rising government programs in order to increase awareness amongst the individuals of emerging countries across the region.
Strong Portfolio and Sales of Zimmer Biomet, Astellas Pharma, and BioLife Solutions to Aid these Companies to Peak their Market Position
On the basis of competitive landscape, the market is fragmented into several national and international players for tissue products, immunosuppressive drugs, and preservation solutions. However, new product launches and focus on strategic acquisitions are among the critical factors driving factors to capturing higher market share. Regarding tissue products, Zimmer Biomet dominated the market because of its prominent portfolio of soft tissue products, including the ‘DeNovo NT Graft’ and the ‘DermaSpan Acellular Dermal Matrix’, which have several indications for knee, hip, ankle, and shoulder. At the same time, Astellas dominates the market due to its strong sales of PROGRAF (tacrolimus) in immunosuppressive drugs. Also, some companies, such as Veloxis Pharmaceuticals, Inc., have pipeline drugs in their portfolio that supports the company's growth.
In terms of preservation solutions, BioLife Solutions is one of the key market players due to its robust cell processing segment, including biopreservation media products. Furthermore, emerging companies, such as MTF Biologics, Dr. Franz Köhler Chemie GmbH, and Paragonix Technologies, are slowly gaining a significant market share owing to the offering of technologically advanced products.
An Infographic Representation of Transplantation Market
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The research report includes a detailed global market overview. The global market is segmented by product type, application, end-user, and geography. The analysis emphasizes crucial aspects such as dynamics of the market, key industry developments, mergers, acquisitions, partnerships, new product launches, overview of technological advancements, regulatory scenarios, number of organ transplants, key industry trends, major market players, and COVID-19 pandemic impact on the global market. Besides this, the report includes insights into the market trends and industry dynamics. Additionally, the report encompasses numerous factors and market statistics contributing to the market's growth.
Value (USD billion)
By Product Type, Application, End-user, and Geography
By Product Type
Fortune Business Insights says that the global market size was USD 12.11 billion in 2021 and is expected to reach USD 27.18 billion by 2029.
In 2021, North America stood at USD 5.08 billion.
Growing at a CAGR of 9.5%, the market will exhibit steady growth in the forecast period (2022-2029).
The tissue transplantation segment is expected to be the leading segment in the market during the forecast period.
The rise in demand for these procedures, technological advancements in tissue products, and favorable government initiatives in the global market are driving the market growth.
Astellas Pharma, BioLife Solutions, and Zimmer Biomet are some of the major market players.
North America dominated the market in 2021.
New product launches, rising government initiatives to increase organ donations, and rise in the number of these procedures across the globe drive the adoption of these products.
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