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Inflammatory Bowel Disease Treatment Market Size, Share & COVID-19 Impact Analysis, By Disease Indication (Ulcerative Colitis and Crohn’s Disease), By Route of Administration (Oral and Injectables), By Drug Class (IL Inhibitors, TNF Inhibitors, Anti-integrin, JAK Inhibitors, Corticosteroids, ASA Drugs, and Others), By Distribution Channel (Hospital Pharmacy and Retail Pharmacy & Other), and Regional Forecast, 2022-2029

Region : Global | Format: PDF | Report ID: FBI106704

 

KEY MARKET INSIGHTS

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The global inflammatory bowel disease treatment market size was valued at USD 23.90 billion in 2021. The market is projected to grow from USD 25.18 billion in 2022 to USD 37.00 billion by 2029, exhibiting a CAGR of 5.7% during the forecast period. The global COVID-19 pandemic has been unprecedented and staggering, with inflammatory bowel disease treatment experiencing lower-than-anticipated demand across all regions compared to pre-pandemic levels. Based on our analysis, the global market exhibited a slower growth of 4.7% in 2020 as compared to 2019.


Globally, the prevalence of ulcerative colitis and Crohn's disease is increasing due to factors such as lifestyle changes in the people, environmental factors, and others. For instance, according to the American Gastroenterological Association, the global prevalence of inflammatory bowel disease is 396 cases per 100,000 persons annually. Additionally, with the increasing emphasis on the early diagnosis of the disease, a higher diagnosis rate of the disease and adequate reimbursement policies in developed countries support the growth of the market. This led to the rising number of patients undergoing treatment for IBD and increased the demand for inflammatory bowel disease treatment drugs such as TNF inhibitors, IL inhibitors, JAK inhibitors, and others in the market.


The growing awareness about the benefits of drugs such as biologics, corticosteroids, and others is increasing the adoption of inflammatory bowel disease therapeutics globally. For instance, according to the research study conducted by Science Direct, in South America, from the total 655 patients studied, biological therapy was used by 36.4% of the patients suffering from Crohn’s disease and 9.1% of the patients suffering from ulcerative colitis.


COVID-19 IMPACT


Delay in Diagnostic Procedures amid COVID-19 to Limit Treatment Rate of IBD


The impact of COVID-19 resulted in slower growth of the inflammatory bowel disease treatment market during the forecast period. Several factors are responsible for the slower treatment rate of the disease, including the closure of the diagnostic centers, travel restrictions, and lockdowns in many countries globally.



  • For instance, according to the article published by BMJ Journals, over 50% of people with IBD were diagnosed without a histological diagnosis due to restrictions placed on endoscopy at over 90% of centers across the U.K., in April 2020, as compared to the same month in 2019.


The market players witnessed a significant decline in revenue generated during 2020. For instance, Pfizer Inc. registered a decline of -3.5% in revenues generated from its inflammation & immunology segment in 2020. Additionally, Bausch Health Companies Inc. registered a decline of -5.8% in the revenues generated from its Salix division in 2020.


However, in 2021, the regulations imposed by the governments were relaxed, and as a result, the visits to hospitals and diagnostic centers increased. Thus, the demand for the drugs was increased in 2021 due to the increasing diagnosis rate of the disease. The major companies in the market observed an increase in revenues of the drugs during 2021. For instance, AbbVie Inc. observed an increase in revenues of HUMIRA by 4.3% in 2021 as compared to the revenue in 2020.


LATEST TRENDS


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Strong Focus on R&D for Treatment of Inflammatory Bowel Disease to Augment Market Growth


Technological development, such as the use of single-cell RNA sequencing, is helping healthcare professionals in the treatment of inflammatory bowel disease. High dimensional technologies such as single-cell RNA sequencing and mass cytometry have been performed on the intestinal specimens collected from the patients suffering from Crohn’s disease or ulcerative colitis.


Several benefits of the single-cell RNA sequencing analysis used to understand the molecular basis of the disease include the development of novel therapeutic approaches, optimizing the individual medicines, and preventing the disease.



  • For instance, in August 2020, The University of California and VA San Diego Healthcare System (VASDHS) used transcriptomic and antigen receptor sequencing strategies to characterize tissue and immune cell features in individuals with or without ulcerative colitis.


These advancements in technology provide an unusual view of immune cell networks in health and disease. They offer a personalized medicine approach to patients suffering from ulcerative colitis and Crohn’s disease.


DRIVING FACTORS


Rising Prevalence of Disease is Presenting a Large Patient Pool Undergoing Treatment


There are numerous factors that are responsible for the increasing prevalence of ulcerative colitis and Crohn’s disease, which are genetic predisposition, environmental triggers, and immune system disturbance. The majority of the patients suffering from ulcerative colitis or Crohn’s disease have a family history of the disorder.



  • For instance, according to the research study conducted by Hopkins Medicine, about 10-15% of the patients suffering from Crohn’s disease have a family history of the disorder. Approximately 5-7% of the patients suffering from ulcerative colitis have a family history of the disorder.


Various government organizations are creating awareness about these diseases in the people by educating them about the symptoms, diagnosis, and treatments available for these conditions. Thus, the rising awareness about the treatment options available and the increasing rate of disease diagnosis in developing countries are anticipated to support the market growth.


Thus, the above-mentioned factors are leading to increasing demand for drugs during the forecast period.


Strong Portfolio of Pipeline Molecules to Increase Product Launches during Forecast Period


The rising prevalence of Crohn’s disease and ulcerative colitis and the increasing awareness of the disease globally are some of the factors responsible for the inflammatory bowel disease treatment market growth. Thus, various key industry players are focusing on R&D and exploring new potential candidates for the IBD treatment.



  • For instance, according to ClinicalTrials.gov., more than 145 clinical studies are active for ulcerative colitis and Crohn’s disease. The majority of the molecules are in phases 3 & 4 of the clinical trials.


Eli Lilly and Company used mirikizumab drug in phase 3 of clinical trials to evaluate the long-term efficacy and safety of mirikizumab in children and adolescents with moderate-to-severe ulcerative colitis or Crohn's disease.


Additionally, the increasing demand for biologics for treating these conditions has influenced market players to expand their portfolios and commercialize their drugs globally. Thus, the rising regulatory approvals for the drugs launched by the key players and increasing patients' preferences for the medications are projected to support the market growth during the forecast period.


RESTRAINING FACTORS


High Cost of Drugs and Limited Reimbursement Policies to Restrict Market Growth


There is a lack of awareness about inflammatory bowel disease in developing countries, reducing the number of patients undergoing treatment. Additionally, high treatment cost, including the drug cost and other cost, is projected to limit the adoption of inflammatory bowel disease treatment in patients.



  • For instance, according to the Crohn’s & Colitis Foundation, the average annual cost of medications per patient for IBD treatment is approximately USD 5,100 in 2020.


Additionally, the adoption of biologics is increasing to treat ulcerative colitis and Crohn’s disease, but the high costs associated with biologics treatment are limiting the market growth.



  • For instance, according to the National Center for Biotechnology Information (NCBI), the average annual cost of Adalimumab per person is about USD 12,343 in the U.K.


In emerging countries, such as India, China, and Russia, there is a lack of reimbursement for IBD treatment, limiting the adoption of these drugs in the region. Thus, the high cost of medications for treating inflammatory bowel disease and the lack of reimbursement policies in developing countries are restricting the market growth during the forecast period.


SEGMENTATION


By Disease Indication Analysis


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Increasing Drug Approvals by Regulatory Authorities for Treatment to Dominate Market


On the basis of disease indication, the market of inflammatory bowel disease treatment is segmented into Crohn's disease and ulcerative colitis.


The Crohn’s disease segment is expected to hold a major share in the market. The growth of this segment is attributed to the increasing prevalence of Crohn’s disease and the number of patients undergoing treatment for Crohn’s disease globally. For instance, according to the Deutsches Ärzteblatt, the prevalence of Crohn’s disease in Germany is approximately 100 to 200 per 100,000 people.


The growth of the ulcerative colitis segment is attributed to increasing drug approvals by regulatory authorities for the treatment of ulcerative colitis and the increasing treatment rate of the disease globally.



  • For instance, in March 2022, AbbVie announced the U.S. Food and Drug Administration (FDA) approval for the drug RINVOQ (upadacitinib) for treating adults with moderate to severely active ulcerative colitis.


By Route of Administration Analysis


Injectables Segment to Hold Largest Market Share


Injectables segment is anticipated to grow due to factors such as increasing adoption of biologics for the treatment of ulcerative colitis & Crohn’s disease and increasing product approvals for biologics. For instance, in February 2021, AbbVie Inc. announced the FDA approval of HUMIRA to treat moderate to severely active ulcerative colitis in pediatric patients. HUMIRA is administered through subcutaneous injections. Thus, the increasing demand for biologics for IBD treatment supports the growth of the injectables segment.


The growth of the oral segment is attributed to the easy availability of oral drugs for the treatment of IBD and the convenience of self-administration of oral drugs for the treatment of mild to moderate ulcerative colitis and Crohn’s disease.


By Drug Class Analysis


Increasing Adoption of Biologics to Dominate the Market


In terms of drug class, the market of inflammatory bowel disease treatment is categorized into IL Inhibitors, TNF inhibitors, anti-integrin, JAK Inhibitors, corticosteroids, ASA drugs, and others.


The TNF inhibitors segment held the leading share of the market. Monoclonal antibodies are used for targeting to induce and maintain remission in patients with inflammatory bowel disease, which supports the segment’s growth in the market. Additionally, the focus of the key market players on the development of TNF inhibitors is responsible for the dominance of the segment.



  • For instance, Celltrion is conducting a phase-3 trial for its CT-P13 SC (Infliximab) – a TNF inhibitor, to evaluate its potential for treating moderate to severe Crohn's disease. Thus, the strong portfolio of pharmaceutical companies & pipeline of TNF inhibitors for the treatment of inflammatory bowel disease is anticipated to drive the growth of the segment


The JAK inhibitors segment held a significant share in the market owing to increasing product approvals for JAK inhibitors, the oral route of administration, and rapid onset of action.


By Distribution Channel Analysis


Hospital Pharmacy Segment to Hold Significant Market Share


In terms of distribution channel, the market is segmented into hospital pharmacy and retail pharmacy & other.


The hospital pharmacy segment dominated the market with a significant share owing to reimbursement policies in developing countries, which cover the high cost of these drugs. For instance, according to Baylor Scott & White, in the U.S., approximately 45% of the costs are covered for the pharmacy, including injectable drugs and others.


The growth of retail pharmacy & other segment is attributed to the increasing demand for the drugs such as JAK inhibitors, a corticosteroid that is easily available in retail pharmacies. Also, globally, the increasing adoption of online pharmacies is supporting the growth of the segment.


REGIONAL INSIGHTS


North America Inflammatory Bowel Disease Treatment Market Size, 2021 (USD Billion)

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The market size in North America stood at USD 9.81 billion in 2021, which was driven by the higher adoption of biologics for the treatment of ulcerative colitis and Crohn’s disease, favorable reimbursement policies for the treatment, and increasing prevalence of these diseases in the U.S. and Canada.



  • For instance, according to the National Center for Biotechnology Information (NCBI), the prevalence of inflammatory bowel disease in Canada will be over 0.75% in 2021.


Europe is projected to hold the second-largest share of the inflammatory bowel disease therapeutics market in 2021. The major factors driving the market growth include the increasing treatment population of the disease in the region. Different treatment options available for the disease are some of the factors that drive the market growth in Europe.


The market in Asia Pacific will exhibit a higher CAGR owing to increasing awareness about ulcerative colitis and Crohn’s disease in the region and increasing approvals for the drugs for the treatment of these diseases.



  • For instance, in December 2021, Eisai Co., Ltd. and Gilead Sciences, Inc. agreed to the commercialization and distribution of filgotinib, an oral, JAK1 preferential inhibitor for indications of ulcerative colitis and Crohn's disease in Asia (South Korea, Taiwan, Hong Kong, and Singapore).


The market in Latin America is growing due to the increasing prevalence of Crohn’s disease and ulcerative colitis, availability of different treatment options, increased healthcare spending, and raising awareness about these conditions in the region.


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The Middle East & Africa market will continue to expand at considerable market share during the forecast period attributable to the lifestyle changes of people and increasing prevalence of smoking, which contribute to the rising prevalence of the disease. Additionally, the number of people seeking the treatment of these diseases is increasing, which is driving the market growth in the region.


KEY INDUSTRY PLAYERS


AbbVie Inc. Leads the Market with its Strong Portfolio of Drugs


The market is consolidated, with a few key players holding a major share of the market. Industry leader AbbVie Inc. holds a dominating place with strong portfolio biologic drugs for the treatment of ulcerative colitis and Crohn’s disease. Successful penetration across major geographies has made the company a leading player worldwide. Takeda Pharmaceutical Company Limited, CELGENE CORPORATION, and Johnson & Johnson Services, Inc. are some of the major players in the market. New product launches and mergers & acquisitions by these key market players are supporting the dominance of these players in the market.



  • For instance, in October 2021, Bristol-Myers Squibb Company announced the approval of Zeposia (ozanimod) by the Committee for Medicinal Products for Human Use (CHMP) for the treatment of adults with moderately to severely active Ulcerative Colitis (UC).

  • In February 2021, the European Commission (EC) granted marketing authorization to CELLTRION INC.’s Yuflyma biosimilar used to treat adult and pediatric Crohn’s disease and ulcerative colitis.


LIST OF KEY COMPANIES PROFILED:



KEY INDUSTRY DEVELOPMENTS:



  • March 2022- AbbVie Inc. announced the U.S. Food and Drug Administration (FDA) approval for RINVOQ (upadacitinib) for the treatment of adults with moderately to severely active Ulcerative Colitis (UC).

  • May 2021- Bristol-Myers Squibb Company announced the U.S. Food and Drug Administration (FDA) approval for Zeposia (ozanimod) 0.92 mg for the treatment of adults with moderately to severely active UC.


REPORT COVERAGE


An Infographic Representation of Inflammatory Bowel Disease Treatment Market

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The market report provides a detailed market analysis. It focuses on key aspects such as leading companies, drug class, disease indication, and distribution channel. Besides this, it offers insights into the market trends, impact of COVID-19, and prevalence of ulcerative colitis and Crohn’s disease, among other key insights. In addition to the factors mentioned above, the report encompasses several factors that have contributed to the growth of the market in recent years.


Report Scope & Segmentation


























































  ATTRIBUTE



  DETAILS



Study Period



2018-2029



Base Year



2021



Estimated Year



2022



Forecast Period



2022-2029



Historical Period



2018-2020



Unit



Value (USD billion)



Segmentation



Disease Indication, Route of Administration, Drug Class, Distribution Channel, and Region



By Disease Indication




  • Ulcerative Colitis

  • Crohn's Disease



By Route of Administration




  • Oral

  • Injectables



By Drug Class




  • IL Inhibitors

  • TNF Inhibitors

  • Anti-integrin

  • JAK Inhibitors

  • Corticosteroids

  • ASA Drugs

  • Others



By Distribution Channel




  • Hospital Pharmacy

  • Retail Pharmacy & Other



By Geography




  • North America (By Disease Indication, By Route of Administration, By Drug Class, By Distribution Channel, and By Country)


    • U.S. (By Disease Indication)

    • Canada (By Disease Indication)


  • Europe (By Disease Indication, By Route of Administration, By Drug Class, By Distribution Channel, and By Country)


    • U.K. (By Disease Indication)

    • Germany (By Disease Indication)

    • France (By Disease Indication)

    • Italy (By Disease Indication)

    • Spain (By Disease Indication)

    • Rest of Europe (By Disease Indication)




  • Asia Pacific (By Disease Indication, By Route of Administration, By Drug Class, By Distribution Channel, and By Country)




    • China (By Disease Indication)

    • Japan (By Disease Indication)

    • India (By Disease Indication)

    • Australia (By Disease Indication)

    • Southeast Asia (By Disease Indication)

    • Rest of Asia Pacific (By Disease Indication)


  • Latin America (By Disease Indication, By Route of Administration, By Drug Class, By Distribution Channel, and By Country)


    • Brazil (By Disease Indication)

    • Mexico (By Disease Indication)

    • Rest of Latin America (By Disease Indication)


  • Middle East & Africa (By Disease Indication, By Route of Administration, By Drug Class, By Distribution Channel, and By Country)




    • GCC (By Disease Indication)

    • South Africa (By Disease Indication)

    • Rest of MEA (By Disease Indication)




Frequently Asked Questions

Fortune Business Insights says that the global market stood at USD 23.90 billion in 2021 and is projected to reach USD 37.00 billion by 2029.

In 2021, the market value stood at USD 23.90 billion.

The market will exhibit steady growth at a CAGR of 5.7% during the forecast period (2022-2029).

By disease indication, the Crohns disease segment will lead the market.

Changing lifestyle along with the genetic factors leading to the rising prevalence of inflammatory bowel disease, strong portfolio of pipeline molecules leading to increasing new product launches, and growing adoption of the biologics for treatment of inflammatory bowel disease to focus on the targeted treatment during the forecast period are the key drivers of the market.

AbbiVie Inc., Takeda Pharmaceutical Company Limited, and Johnson & Johnson Services, Inc. are the major players in the market.

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Inflammatory Bowel Disease Treatment Market  Size, Share and Global Industry Trend Forecast till 2026
  • May, 2022
  • 2021
  • 2018-2020
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