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The U.S. sickle cell disease treatment market size was worth USD 1.44 billion in 2022 and is projected to grow at a CAGR of 17.3% during the forecast period.
A sickle cell disease is a group of blood disorders that is inherited. It includes hemoglobin sickle cell disease, hemoglobin SS disease, sickle cell anemia, and others, causing red blood cell deformation. Its treatment includes blood transfusions, bone-marrow transplants, and medications. The prevalence of sickle cell disease has been increasing significantly.
The rising prevalence of the disease has created awareness among the population about effective treatment of the condition. Moreover, the increasing market players’ focus on effective drug development has led to an introduction of novel drugs in the U.S. market. These factors are fueling the U.S. sickle cell disease treatment market growth.
During the COVID-19 pandemic in 2020, the U.S. market remained unaffected. This was due to the new approvals and commercialization of new drugs in the pharmacotherapy segment during 2019-2020.
Increasing Emphasis on R&D for Sickle Cell Disease Treatment
The burden of sickle cell disease has been significantly increasing. Citing this, the government and other organizations are emphasizing improving the accessibility to disease treatment. The government body in the U.S. has been working on creating awareness about the disease and available treatment options in order to manage the disease in the country.
Such initiatives have been fueling the funding and financial support in the R&D for effective sickle cell disease treatment development.
Approval of Advanced Pharmacotherapy Drugs to Fuel the Market Growth
Patients with sickle cell disease often experience episodes of acute pain caused by vaso-occlusive crisis (VOC), one of the most common complications of the disease. For instance, the American Society of Hematology (ASH) published a study in 2019 including 16,092 patients. The duration of the study was from January 2001 to June 2018. Out of the total patients, around 14.0% of the patients suffered at least 1 VOC in a year. Moreover, as per the same study, 21.2% of the patients suffered at least 2 VOCs in a year.
Market players have increased their focus on the launch of innovative drugs to control the disease severity and prevent the complications associated with the disease.
The increasing approval of such pharmacotherapy drugs and rising demand for these drugs for effectively managing the disease is fueling the market growth.
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Novo Nordisk A/S’ FT-4202 is currently in phase II clinical trial and the estimated completion of the phase II clinical trial is in July 2025. FT-4202 is anticipated to be commercialized in 2028. Similarly, Dianthus Therapeutics’ MGTA-145 is in the phase II clinical trial, and its estimated commercialization is in 2027. Moreover, Pfizer Inc.’s Inclacumab is in phase III clinical trials and is expected to launch in 2025.
High Treatment Cost is Hampering the Market Growth
A significant increase in the prevalence of sickle disease has fueled the demand for effective treatment options. Pharmacotherapy drugs have proven to be quite effective in sickle cell disease management. However, treatment through these drugs is costly.
Such high cost of these drugs limits their adoption among the population, negatively impacting the market growth.
By Treatment Modality Analysis
Based on treatment modality, the U.S. market is classified into bone marrow transplant, blood transfusion, and pharmacotherapy. The pharmacotherapy segment is bifurcated into hydroxyurea and branded products. The branded products are further sub-segmented into Adakveo, Oxbryta, Endari, Zynteglo, CTX001, PYRUKYND (Mitapivat), Inclacumab, Vamifeport (VIT-2763), ALXN1820, MGTA-145, FT-4202, and GBT021601.
The pharmacotherapy segment is expected grow at the fastest CAGR during the forecast period. The approval and commercialization of pipeline drugs is expected to fuel the segment’s growth during the forecast period. For instance, Global Blood Therapeutics’ pipeline drug Inclacumab, which is currently undergoing phase III clinical trials, is expected to launch in 2025 in the U.S.
On the basis of end-user, the U.S. market is trifurcated into specialty clinics, hospitals, and others.
The hospitals segment dominated the market in 2022. Bone marrow transplant and blood transfusion procedures are mostly conducted in hospitals. This factor is responsible for the segment’s dominance. Moreover, the increasing hospital admissions due to VOC episodes has also been fueling the segment’s growth.
Market players such as Global Blood Therapeutics Inc. (Pfizer Inc.), Novartis AG, and Emmaus Medical, Inc. accounted for a significant U.S. sickle cell disease treatment market share in 2022. The growth of these companies in the market is attributed to the market players’ increasing emphasis on partnerships to expand the accessibility of their products.
Other players in the market include Forma Therapeutics, Inc., Alexion Pharmaceuticals, and Magenta Therapeutics, Inc. These players have increased their focus on developing advanced pharmacotherapy products to strengthen their position in the U.S. market.
An Infographic Representation of U.S. Sickle Cell Disease Treatment Market
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The U.S. sickle cell disease treatment market analysis report provides a detailed analysis of the market. The report includes market segmentation, key points such as pipeline analysis, and the product portfolio of the key players operating in the U.S. market. Additionally, it includes the adoption of pharmacotherapy drugs in the U.S., new product launches, key industry developments such as mergers, collaborations, acquisitions, and the impact of COVID-19 pandemic on the market. Besides this, the report also offers insights into the market trends and highlights key industry dynamics. In addition to the aforementioned factors, it encompasses several factors that have contributed to the growth of the market over recent years.
CAGR of 17.3% from 2023-2030
Value (USD Billion)
By Treatment Modality
Fortune Business Insights says that the U.S. market was worth USD 1.44 billion in 2022.
The market is expected to exhibit a CAGR of 17.3% during the forecast period (2023-2030).
By treatment modality, the pharmacotherapy segment is expected to grow at the fastest CAGR during the forecast period.
Global Blood Therapeutics Inc. (Pfizer Inc.), Novartis AG, and Emmaus Medical, Inc. are the top players.
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